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首页> 外文期刊>Environmental Science & Technology >Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish
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Parental Transfer of Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Endocrine Disruption in Zebrafish

机译：斑马鱼的父母对多溴联苯醚（PBDEs）的转移和甲状腺内分泌干扰

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摘要

Polybrominated diphenyl ethers (PBDEs) have die potential to disrupt the thyroid endocrine system. The objective of the present study was to characterize the disrupting effects of long-term exposure on the thyroid endocrine system in adult fish and their progeny following parental exposure to PBDEs. Zebrafish {Danio rerio) embryos were exposed to environmentally relevant concentrations (1,3, and 10μg/L) of the PBDE mixture DE-71 for 5 months until sexual maturation. In the F0 generation, exposure to DE-71 significantly increased plasma thyroxine (T4) but not 3,S3'-Wiodothyronine (T3) in females. This increased T4 was accompanied by decreased mRNA levels of cortkotropin-releasing hormone (CKH) and thyrotropin β-subunit (TSHfi) in the brain. The F1 generation was further examined with or without continued DE-71 treatment conditions. Exposure to DE-71 in the F0 fish caused significant increases in T4 and T3 levels in the Fl larvae and modified gene expressions in the hypothalamic~ pituitary-thyroid axis (HPT axis) under both conditions. Decreased hatching and inhibition ofgrowth in the Fl offspring were observed in the condition without DE-71 treatment Continued DE-71 treatment in the Fl embryos/larvae resulted in further decreased hatching, and increased malformation rates compared with those without DE-71 exposure. Analysis of Fl eggs indicated that parental exposure to DE-71 could result in a transfer of PBDEs and thyroid hormones (THs) to their offspring. For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toncity in subsequent nonexposed generations.
机译：多溴二苯醚（PBDEs）具有破坏甲状腺内分泌系统的潜力。本研究的目的是表征父母暴露于多溴二苯醚后长期暴露对成年鱼及其后代甲状腺内分泌系统的破坏作用。将斑马鱼（Danio rerio）胚胎暴露于与环境相关浓度（1.3和10μg/ L）的PBDE混合物DE-71中5个月，直到性成熟。在F0代中，女性暴露于DE-71会显着增加血浆甲状腺素（T4），但不会增加3，S3'-Wiodothyronine（T3）。 T4升高伴随着大脑中促肾上腺皮质激素释放激素（CKH）和促甲状腺激素β亚基（TSHfi）的mRNA水平降低。在有或没有持续的DE-71处理条件下进一步检查了F1代。在两种情况下，在F0鱼中暴露于DE-71都会导致Fl幼虫的T4和T3水平显着升高，并导致下丘脑-垂体-甲状腺轴（HPT轴）的基因表达发生改变。在未进行DE-71处理的情况下，观察到了F1后代的孵化减少和生长受抑制。与未暴露于DE-71的情况相比，在F1胚胎/幼虫中继续进行DE-71处理导致孵化进一步减少，畸形率增加。对F1卵的分析表明，父母暴露于DE-71可能导致PBDEs和甲状腺激素（THs）转移至其后代。首次，我们证明了父母暴露于低浓度的PBDEs可能会影响后代中的TH，并在随后的非暴露世代中影响跨代PBDEs诱导的音调。

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  • 来源
    《Environmental Science & Technology》 |2011年第24期|p.10652-10659|共8页
  • 作者

    Liqin Yu; James C. W. Lam; Yongyong Guo; Rudolf S. S. Wu; Paul K. S. Lam; Bingsheng Zhou;

  • 作者单位

    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China;

    State Key Laboratory in Marine Pollution, Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China;

    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China;

    School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, China;

    State Key Laboratory in Marine Pollution, Department of Biology and Chemistry, City University of Hong Kong, Hong Kong SAR, China;

    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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