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首页> 外文期刊>Environmental Science & Technology >Ecotoxicogenomics: Bridging the Gap between Genes and Populations
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Ecotoxicogenomics: Bridging the Gap between Genes and Populations

机译：生态毒理基因组学：弥合基因与种群之间的鸿沟

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摘要

Ecotoxicogenomics might help solving open questions that cannot be answered by standard ecotoxicity tests currently used in environmental risk assessment. Changes in gene expression are claimed to serve potentially as early warning indicators for environmental effects and as sensitive and specific ecotoxicological end points. Ecotoxicogenomics focus on the lowest rather than the highest levels of biological organization. Our aim was to explore the links between gene expression responses and population level responses, both mechanistically (conceptual framework) and correlatively (Species Sensitivity Distribution). The effects of cadmium on aquatic species were compared for gene level responses (Lowest Observed Effect Concentrations) and individual level responses (median Lethal Concentrations, IC_(50), and No Observed Effect Concentrations, NOEC). Responses in gene expression were on average four times above the NOEC and eleven times below the LC_(50) values. Currently, use of gene expression changes as early warning indicators of environmental effects is not underpinned due to a lack of data. To confirm the sensitivity claimed by ecotoxicogenomics more testing at low concentrations is needed. From the conceptual framework, we conclude that for a mechanistic gene population link in risk management research is required that includes at least one meaningful end point at each level of organization.
机译：生态毒理基因组学可能有助于解决目前环境风险评估中使用的标准生态毒理测试无法解决的未解决问题。据称基因表达的变化有可能作为环境影响的预警指标，并作为敏感和特定的生态毒理学终点。生态毒理基因组学侧重于最低而不是最高水平的生物组织。我们的目的是从机制（概念框架）和相关性（物种敏感性分布）的角度探讨基因表达反应与种群水平反应之间的联系。比较了镉对水生生物的影响，包括基因水平响应（最低观测效应浓度）和个体水平响应（中毒致死浓度，IC_（50）和无观测效应浓度，NOEC）。基因表达的响应平均比NOEC高4倍，比LC_（50）值低11倍。目前，由于缺乏数据，基因表达变化作为环境影响的预警指标的使用尚无依据。为了确认生态毒理基因组学声称的敏感性，需要在低浓度下进行更多测试。从概念框架出发，我们得出结论，对于风险机制研究中的一种机制基因种群链接，需要在组织的每个级别上至少包含一个有意义的终点。

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  • 来源
    《Environmental Science & Technology》 |2010年第11期|P.4328-4333|共6页
  • 作者

    ANASTASIA FEDORENKOVA; J. ARIE VONK; H. J. ROB LENDERS; N. JOOP OUBORG; ANTON M. BREURE; A. JAN HENDRIKS;

  • 作者单位

    Department of Environmental Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    rnLaboratory for Ecological Risk Assessment, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands Department of Environmental Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    rnDepartment of Environmental Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    rnDepartment of Molecular Ecology, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    rnLaboratory for Ecological Risk Assessment, National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands Department of Environmental Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

    rnDepartment of Environmental Science, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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