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首页> 外文期刊>Environmental Science & Technology >Metabolites of the Aquatic Pollutant Diclofenac in Fish Bile
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Metabolites of the Aquatic Pollutant Diclofenac in Fish Bile

机译：鱼胆汁中水生污染物双氯芬酸的代谢产物

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摘要

The uptake and metabolism of anti-inflammatory drug diclofenac (DCR was studied by exposing rainbow trout (Oncorhynchus mykiss) to DCF intraperitoneally, and via water at concentration of 1.7 μg L-1. The bile was collected and the formed metabolites were identified. The identification was based on the exact mass determinations by a time-of-flight mass analyzer and on the studies of fragments and fragmentation patterns of precursor ions by an ion trap mass analyzer. The main metabolites found were acyl glucumnides of hydroxylated DCFs. In addition, one ether glucuronide of hydroxylated DCF was found. Also, unmetabolized DCF was detected in the bile. The total bioconcentraton factors (BCF_(total-bile) for DCF and its metabolites) in rainbow trout bile, varied between individuals and was roughly estimated to range from 320 to 950. These findings suggest that fish living downstream the wastewater treatment plants (WWTPs) and which are chronically exposed to the drug may accumulate the drug and its metabolites in the bile.
机译：通过将虹鳟鱼（Oncorhynchus mykiss）腹膜内暴露于DCF，并以1.7μgL-1的浓度经水研究抗炎药双氯芬酸（DCR）的吸收和代谢，收集胆汁并鉴定形成的代谢产物。鉴定是基于飞行时间质量分析仪的精确质量测定以及离子阱质量分析仪对前体离子的碎片和碎片模式的研究，发现的主要代谢物是羟基化DCF的酰基葡糖苷。发现了一个羟基化DCF的醚葡萄糖醛酸化物，并且在胆汁中检测到了未代谢的DCF，虹鳟胆汁中的总生物浓缩因子（BCF_（总胆汁）和DCF及其代谢产物）因人而异，并大致估计在范围内从320到950。这些发现表明，生活在废水处理厂（WWTP）下游并且长期接触该药物的鱼类可能会积累g及其在胆汁中的代谢产物。

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  • 来源
    《Environmental Science & Technology》 |2010年第19期|p.7213-7219|共7页
  • 作者

    JENNY-MARIA KALLIO; MARJA LAHTI; AIMO OIKARI; LEIF KRONBERG;

  • 作者单位

    Abo Akademi University. Laboratory of Organic chemistry,Biskopsgatan 8, FI-20500 Abo, Finland;

    rnUniversity of lyvaskyla. Department of Biological and Environmental Sciences, FI-40014 University of lyvaskyla, Finland;

    rnUniversity of lyvaskyla. Department of Biological and Environmental Sciences, FI-40014 University of lyvaskyla, Finland;

    rnAbo Akademi University. Laboratory of Organic chemistry,Biskopsgatan 8, FI-20500 Abo, Finland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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