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首页> 外文期刊>Environmental Science & Technology >The Interaction of Ruminant PrP~(Sc) with Soils Is Influenced by Prion Source and Soil Type
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The Interaction of Ruminant PrP~(Sc) with Soils Is Influenced by Prion Source and Soil Type

机译：反刍动物PrP〜（Sc）与土壤的相互作用受Is离子来源和土壤类型的影响

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摘要

The persistence of prions within the environment is implicated in the horizontal transmission of ovine scrapie and cervid chronic wasting disease. Description of the interaction of prion strains derived from their natural hosts with a range of soil types is imperative in understanding how prions persist in the environment and, therefore, the characteristics of prion transmission. Here, we demonstrate that all detectable ovine scrapie and bovine BSE PrP~(Sc) bind to a range of soil types within 24 h. This highly efficient binding of prions to soils is characterized by truncation of desorbed PrP~(Sc) in a soil-dependent manner, with clay-rich soils resulting in N-terminal truncation of the PrP~(Sc) and sand-rich soils yielding full length PrP~(Sc) species. PrP~(Sc) did not migrate through soil columns during incubation for up to 18 months, and for all combinations of soil and prion types, a decrease in recoverable PrP~(Sc) was seen over time. Persistence of PrP~(Sc) within soil and their interaction with soil particles of distinct sizes was dictated by both the soil type and the source of the prion, with ovine scrapie being apparently more persistent in some soils than cattle BSE. These data indicate that natural ruminant prion strains are stable in the soil environment for at least 18 months and that PrP~(Sc)-soil interaction is dictated by both the soil properties and the strain/host species of PrP~(Sc).
机译：environment病毒在环境中的持续存在与绵羊瘙痒病和宫颈慢性消耗性疾病的水平传播有关。描述从自然宿主衍生的病毒菌株与一系列土壤类型之间的相互作用，对于理解病毒在环境中的持久性以及and病毒的传播特性至关重要。在这里，我们证明了所有可检测到的羊瘙痒病和牛BSE PrP〜（Sc）在24小时内都与一定范围的土壤类型结合。 highly病毒与土壤的这种高效结合的特征在于以依赖土壤的方式截断解吸的PrP〜（Sc），富含粘土的土壤导致PrP〜（Sc）的N端截断，并且富沙的土壤产生全长PrP〜（Sc）种类。 PrP〜（Sc）在孵育过程中长达18个月没有通过土壤柱迁移，并且对于土壤和病毒类型的所有组合，可回收的PrP〜（Sc）随时间下降。 PrP〜（Sc）在土壤中的持久性以及它们与不同大小的土壤颗粒的相互作用取决于土壤类型和病毒的来源，与某些牛的疯牛病相比，绵羊瘙痒病在某些土壤中显然更持久。这些数据表明，天然的反刍动物ion病毒菌株在土壤环境中稳定了至少18个月，并且PrP〜（Sc）-土壤相互作用是由土壤特性和PrP〜（Sc）的菌株/宿主物种决定的。

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  • 来源
    《Environmental Science & Technology》 |2010年第22期|p.8503-8508|共6页
  • 作者

    BEN C. MADDISON; JONATHAN P. OWEN; KEITH BISHOP; GEORGE SHAW; HELEN C. REES; KEVIN C. GOUGH;

  • 作者单位

    ADAS U.K., Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, U.K., School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD. U.K.;

    ADAS U.K., Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, U.K., School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD. U.K.;

    ADAS U.K., Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, U.K., School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD. U.K.;

    Division of Agricultural and Environmental Sciences, University Park,NG7 2RD, U.K.;

    ADAS U.K., Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, U.K., School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire, LE12 5RD. U.K.;

    University of Nottingham, Nottingham, NG7 2RD, U.K;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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