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首页> 外文期刊>Environmental Science & Technology >Effects of Soluble Cadmium Salts Versus CdSe Quantum Dots on the Growth of Planktonic Pseudomonas aeruginosa
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Effects of Soluble Cadmium Salts Versus CdSe Quantum Dots on the Growth of Planktonic Pseudomonas aeruginosa

机译：可溶性镉盐与CdSe量子点对浮游植物铜绿假单胞菌生长的影响

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摘要

With their increased use, engineered nanomaterials (ENMs) will enter the environment where they may be altered by bacteria and affect bacterial processes. Metallic ENMs, such as CdSe quantum dots (QDs), are toxic due to the release of dissolved heavy metals, but the effects of cadmium ions versus intact QDs are mostly unknown. Here, planktonic Pseudomonas aeruginosa PG201 bacteria were cultured with similar total cadmium concentrations as eitherfully dissolved cadmium acetate (Cd(CH_3COO)_2) or ligand capped CdSe QDs, and cellular morphology, growth parameters, intracellular reactive oxygen species (ROS), along with the metal and metalloid fates were measured. QDs dissolved partially in growth media, but dissolution was less in biotic cultures compared to sterile controls. Dose-dependent growth effects were similar for low concentrations of either cadmium salts or QDs, but effects differed above a concentration threshold of 50 mg/L (total cadmium basis) where (1) the growth of QD-treated cells was more impaired, (2) the membranes of QD-grown cells were damaged, and (3) QD-grown cells contained QD-sized CdSe cytoplasmic inclusions in addition to Se° and dissolved cadmium. For most concentrations, intracellular ROS were higher for QD-versus cadmium salts-grown bacteria. Taken together, QDs werernmore toxic to this opportunistic pathogen than cadmium ions, and were affected by cells through QD extracellular stabilization, intracellular enrichment, and cell-associated decay.
机译：随着其用途的增加，工程纳米材料（ENMs）将进入环境，在这种环境中，它们可能会被细菌改变并影响细菌进程。金属ENM（例如CdSe量子点（QD））由于释放溶解的重金属而具有毒性，但是镉离子相对于完整QD的影响尚不清楚。在这里，以与完全溶解的乙酸镉（Cd（CH_3COO）_2）或配体封端的CdSe QD相似的总镉浓度培养浮游铜绿假单胞菌PG201细菌，并观察细胞形态，生长参数，细胞内活性氧（ROS）以及测量了金属和准金属的命运。 QDs在生长培养基中部分溶解，但与无菌对照相比，在生物培养物中的溶解度更低。对于低浓度的镉盐或QD，剂量依赖性的生长效应相似，但在浓度阈值50 mg / L（以总镉为基准）以上时，其效应有所不同，其中（1）经过QD处理的细胞的生长受到更大的损害，（ 2）QD生长的细胞膜受损，（3）QD生长的细胞除Se°和溶解的镉外，还包含QD大小的CdSe细胞质内含物。对于大多数浓度，QD与镉盐生长细菌的细胞内ROS较高。总体而言，QD对这种机会病原体的毒性比镉离子强，并且通过QD细胞外稳定，细胞内富集和细胞相关的衰变而受到细胞的影响。

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  • 来源
    《Environmental Science & Technology》 |2009年第7期|2589-2594|共6页
  • 作者

    JOHN H. PRIKSTER; PETER K. STOIMENOV; RANDALL E. MIELKE; SAMUEL M. WEBB; CHRISTOPHER EHRHARDT; JIN PING ZHANG; GALEN D. STUCKY; PATRICIA A. HOLDEN;

  • 作者单位

    Donald Bren School of Environmental Science & Management, University of California, Santa Barbara;

    Department of Chemistry and Biochemistry, University of California, Santa Barbara;

    Center for Life Detection, Jet Propulsion Laboratory, California Institute of Technology;

    Stanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center;

    Earth Sciences, University of California, Santa Barbara;

    Materials Research Laboratory, University of California, Santa Barbara;

    Department of Chemistry and Biochemistry, University of California, Santa Barbara;

    Donald Bren School of Environmental Science & Management, University of California, Santa Barbara;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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