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首页> 外文期刊>Environmental Science & Technology >Tracking the Pathways of Human Exposure to Perfluorocarboxylates
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Tracking the Pathways of Human Exposure to Perfluorocarboxylates

机译：追踪人类暴露于全氟羧酸盐的途径

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摘要

Recent analyses of perfluorooctanoate (PFOA) in human blood sera show that the background-exposed population in industrialized countries worldwide exhibits a narrow concentration range; arithmetic means of published studies range between 2 and 8μg/L PFOA, with the exception of a few outlier studies. The globally comparable human serum concentrations of PFOA and characteristic dominance of PFOA with respect to other perfluorocarboxylate (PFCA) homologues indicate that exposure pathways of humans differ from those of wildlife, where perfluorononanoate (PFNA) is often the dominant homologue.The observed correlations between perfluorooctane sulfonate (PFOS) and PFOA in human serum together with a simultaneous downward time trend of these compounds in human blood sera and blood spots from the year 2000 onward indicate a connection between historical perfluorooctanesulfonyl (POSF) production (phased out by the major manufacturer in 2000-2002) and exposure to both PFOS and PFOA. A comparison of estimated daily intakes to humans based on samples from exposure media (collected post 2000) indicates that food intake is the major contemporary exposure pathway for the background population, whereas drinking water exposure is dominant for populations near sources of contaminated drinking water. A one-compartment pharmacokinetic model used to back-calculate daily intakes from serum levels is shown to provide agreement within a factor of 1.5-5.5 of the daily intakes derived from exposure media, which provides further supporting evidence that dietary exposure is a major ongoing exposure pathway of PFOA to the background population.
机译：最近对人体血液中全氟辛酸（PFOA）的分析表明，世界范围内工业化国家的本底暴露人群的浓度范围很窄。除少数异常研究外，已发表研究的算术平均值在2至8μg/ L PFOA之间。相对于其他全氟羧酸盐（PFCA）同源物而言，全球可比的人血清PFOA浓度和PFOA的特征优势表明，人的暴露途径不同于野生生物，而全氟壬酸（PFNA）通常是主要的同源物。从2000年开始，人血清中的磺酸盐（PFOS）和PFOA以及这些化合物在人血清中的同时下降趋势和血点表明历史的全氟辛烷磺酰基（POSF）生产之间存在关联（主要制造商于2000年淘汰-2002），并同时接触PFOS和PFOA。根据来自接触介质的样本（2000年后收集）估算的人类每日摄入量的比较表明，食物摄入量是本底人群当代主要的接触途径，而饮用水接触量在受污染饮用水源附近的人群中占主导地位。单室药代动力学模型可从血清水平反算每日摄入量，显示出在暴露介质每日摄入量的1.5-5.5倍范围内达成一致，这提供了进一步的支持性证据，表明饮食摄入是主要的持续暴露PFOA到背景人群的途径。

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  • 来源
    《Environmental Science & Technology》 |2009年第15期|5565-5575|共11页
  • 作者

    ROBIN VESTERGREN; IAN T. COUSINS;

  • 作者单位

    Department of Applied Environmental Science (ITM), Stockholm University, Svnnte Arrhenius vaeg 8c, SE-10691 Stockholm, Sweden;

    Department of Applied Environmental Science (ITM), Stockholm University, Svnnte Arrhenius vaeg 8c, SE-10691 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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