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首页> 外文期刊>Environmental Science & Technology >Effect of Acute Copper Sulfate Exposure on Olfactory Responses to Amino Acids and Pheromones in Goldfish (Carassius auratus)
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Effect of Acute Copper Sulfate Exposure on Olfactory Responses to Amino Acids and Pheromones in Goldfish (Carassius auratus)

机译：急性硫酸铜暴露对金鱼（Car鱼）对氨基酸和信息素的嗅觉响应的影响

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Exposure of olfactory epithelium to environmentally relevant concentrations of copper disrupts olfaction in fish. To examine the dynamics of recovery at both functional and morphological levels after acute copper exposure, unilateral exposure of goldfish olfactory epithelia to 100 μM CuSO_4 (10 min) was followed by electro-olfactogram (EOGI recording and scanning electron microscopy. Sensitivity to amino acids (L-arginine and L-serine), generally considered food-related odorants, recovered most rapidly (three days), followed by that to catecholamines (3-O-methoxytyramine), bile acids (taurolithocholic acid) and the steroid pheromone, 17,20β-dihydroxy-4-pregnen-3-one 20-sulfate, which took 28 days to reach full recovery. Sensitivity to the postovulatory pheromone prostaglandin F_(2α) had not fully recovered even at 28 days. These changes in sensitivity were correlated with changes in the recovery of ciliated and microvillous receptor cell types. Microvillous cells appeared largely unaffected by CuSO_4 treatment Cilia in ciliated receptor neurones, however, appeared damaged one day post-treatment and were virtually absent after three days but had begun to recover after 14 days. Together, these results support the hypothesis that microvillous receptor neurones detect amino acids whereas ciliated receptor neurones were not functional and are responsible for detection of social stimuli (bile acids and pheromones). Furthermore, differences in sensitivity to copper may be due to different transduction pathways in the different cell types.
机译：嗅觉上皮暴露于与环境相关的铜浓度会破坏鱼类的嗅觉。为了检查急性铜暴露后功能和形态水平的恢复动态，将金鱼嗅觉上皮细胞单侧暴露于100μMCuSO_4（10分钟），然后进行电子嗅觉记录（EOGI记录和扫描电子显微镜检查。对氨基酸的敏感性（ L-精氨酸和L-丝氨酸通常被认为是与食物有关的增味剂，其恢复最快（三天），其次是儿茶酚胺（3-O-甲氧基酪胺），胆汁酸（牛磺石胆酸）和类固醇信息素。 20β-二羟基-4-孕烯-3-酮20硫酸盐，需要28天才能完全恢复，对排卵后信息素前列腺素F_（2α）的敏感性甚至在28天时仍未完全恢复，这些敏感性变化与纤毛和微绒毛受体细胞类型恢复的变化；纤毛细胞似乎在很大程度上不受CuSO_4处理的纤毛影响，但在纤毛受体神经元中出现了损害。 d在三天后实际上不存在，但在14天后开始恢复。总之，这些结果支持以下假设：微绒毛受体神经元可检测氨基酸，而纤毛受体神经元则无功能，并负责检测社会刺激（胆汁酸和信息素）。此外，对铜敏感性的差异可能是由于不同细胞类型中不同的转导途径所致。

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  • 来源
    《Environmental Science & Technology》 |2009年第21期|8393-8399|共7页
  • 作者

    NIKOLAY N. KOLMAKOV; PETER C. HUBBARD; ORLANDO LOPES; ADELINO V. M. CANARIO;

  • 作者单位

    Centra de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal;

    Centra de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal;

    Centra de Ecologia e Ambiente, Universidade de Evora, 7002-554 Evora, Portugal;

    Centra de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal;

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