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首页> 外文期刊>Environmental Science & Technology >Serum Concentrations of Polybrominated Diphenyl Ethers (PBDEs) and Polybrominated Biphenyl (PBB) in the United States Population: 2003-2004
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Serum Concentrations of Polybrominated Diphenyl Ethers (PBDEs) and Polybrominated Biphenyl (PBB) in the United States Population: 2003-2004

机译：2003-2004年美国人口中多溴联苯醚（PBDEs）和多溴联苯（PBB）的血清浓度

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Polybrominated diphenyl ethers (PBDEs) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) are chemicals known as brominated flame retardants. We have assessed the exposure status of the United States population to PBDEs and BB-153 and explored associations with demographic information, including participants' age, sex, and race/ethnicity. A total of 2,062 serum samples, from participants in the National Health and Nutrition Examination Survey (NHANES) 2003-2004 aged 12years and older, were analyzed for PBDEs and BB-153; stratified and regression analyses were used to examine levels among demographic groups. The congener with the highest serum concentration was 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) [geometric mean 20.5 ng/g lipid]; followed by 2,2',4,4',5,5'-hexaBDE (BDE-153) [5.7 ng/g lipid]; 2,2',4,4',5-pentaBDE (BDE-99) [5.0 ng/g lipid; a value equal to the highest limit of detection for an individual sample]; 2,2',4,4',6-pentaBDE (BDE-100) [3.9 ng/g lipid]; BB-153 [2.3 ng/g lipid]; and 2,4,4'-triBDE (BDE-28) [1.2 ng/g lipid]. For BDE-47, we observed no significant difference in the least-squares geometric mean (LSGM) by sex, but with age we found both a linear decrease (p = 0.01) and a positive quadratic trend (p = 0.01). Its LSGM, 27.9 ng/lipid, in the 12-19 year olds decreased to 17.2 ng/g lipid in the 40-49 year group, and then curved upward to 20.4 ng/g lipid in the ≥ 60 years olds. Mexican Americans had the highest LSGM of BDE-47 (24.5 ng/g lipid), which was significantly higher than that of non-Hispanic whites (19.7 ng/g lipid, p = 0.01). Adults 60 years and older were twice as likely as adults 20-59 years old to have a serum BDE-47 concentration above the 95th percentile [p = 0.02).These data provide needed exposure assessment data for public health decisions.
机译：多溴联苯醚（PBDEs）和2,2'，4,4'，5,5'-六溴代二苯（BB-153）是被称为溴化阻燃剂的化学物质。我们评估了美国人口对多溴二苯醚和BB-153的接触状况，并与人口统计信息（包括参与者的年龄，性别和种族/民族）进行了探索。从2003年至2004年的12岁及12岁以上的美国国家健康与营养检查调查（NHANES）的参与者中，总共对2062份血清样本进行了多溴二苯醚和BB-153的分析；进行了分层和回归分析，以检查人口统计学水平。血清浓度最高的同类物是2,2'，4,4'-四溴二苯醚（BDE-47）[几何平均数20.5 ng / g脂质]；其次是2,2'，4,4'，5,5'-hexaBDE（BDE-153）[5.7 ng / g脂质]; 2,2'，4,4'，5-五溴二苯醚（BDE-99）[5.0 ng / g脂质;等于单个样品的最高检出限的值]； 2,2'，4,4'，6-五溴二苯醚（BDE-100）[3.9 ng / g脂质]; BB-153 [2.3 ng / g脂质]；和2,4,4'-triBDE（BDE-28）[1.2 ng / g脂质]。对于BDE-47，我们发现按性别划分的最小二乘几何平均值（LSGM）没有显着差异，但是随着年龄的增长，我们发现线性下降（p = 0.01）和正二次趋势（p = 0.01）。在12-19岁的儿童中，其LSGM为27.9 ng / g脂质，在40-49岁的人群中为17.2 ng / g脂质，然后在60岁以上的人群中向上弯曲至20.4 ng / g脂质。墨西哥裔美国人的LSGM为BDE-47最高（24.5 ng / g脂质），明显高于非西班牙裔白人（19.7 ng / g脂质，p = 0.01）。 60岁及以上的成年人血清BDE-47浓度高于95％百分数的可能性是20-59岁的成年人的两倍（p = 0.02）。这些数据为公共卫生决策提供了所需的暴露评估数据。

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