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首页> 外文期刊>Environmental Science & Technology >Persistence of Pathogenic Prion Protein during Simulated Wastewater Treatment Processes
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Persistence of Pathogenic Prion Protein during Simulated Wastewater Treatment Processes

机译：模拟废水处理过程中致病性Pri病毒蛋白的持久性

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Transmissible spongiform encephalopathies (TSEs, prion diseases) are a class of fatal neurodegenerative diseases affecting a variety of mammalian species including humans. A misfolded form of the prion protein (PrP~(TSE)) is the major, if not sole, component of the infectious agent. Prions are highly resistant to degradation and to many disinfection procedures suggesting that, if prions enter wastewater treatment systems through sewers and/or septic systems (e.g., from slaughterhouses, necropsy laboratories, rural meat processors, private game dressing) or through leachate from landfills that have received TSE-contaminated material, prions could survive conventional wastewater treatment. Here, we report the results of experiments examining the partitioning and persistence of PrP~(TSE) during simulated wastewater treatment processes including activated and mesophilic anaerobic sludge digestion. Incubation with activated sludge did not result in significant PrP~(TSE) degradation. PrP~(TSE) and prion infectivity partitioned strongly to activated sludge solids and are expected to enter biosolids treatment processes. A large fraction of PrP~(TSE) survived simulated mesophilic anaerobic sludge digestion. The small reduction in recoverable PrP~(TSE) after 20-d anaerobic sludge digestion appeared attributable to a combination of declining extractability with time and microbial degradation. Our results suggest that if prions were to enter municipal wastewater treatment systems, most would partition to activated sludge solids, survive mesophilic anaerobic digestion, and be present in treated biosolids.
机译：传染性海绵状脑病（TSE 、,病毒疾病）是一类致命的神经退行性疾病，会影响包括人类在内的多种哺乳动物。 fold病毒蛋白（PrP〜（TSE））的错误折叠形式是传染原的主要成分，即使不是唯一的成分。 ions病毒具有很高的抗降解能力和许多消毒程序，这表明，如果病毒通过下水道和/或化粪池系统（例如，来自屠宰场，尸检实验室，农村肉类加工商，私人野味敷料）或通过垃圾掩埋场的渗滤液进入废水处理系统，如果收到受TSE污染的材料，病毒可以在常规废水处理中幸存下来。在这里，我们报告了在模拟废水处理过程（包括活化和中温厌氧污泥消化）中检查PrP〜（TSE）的分配和持久性的实验结果。用活性污泥孵育不会导致PrP〜（TSE）明显降解。 PrP〜（TSE）和病毒的感染力强烈分配到活性污泥固体中，并有望进入生物固体处理过程。大部分的PrP〜（TSE）在模拟的嗜温厌氧污泥消化中幸存下来。厌氧污泥消化20天后，可回收的PrP〜（TSE）的少量减少似乎是由于可萃取性随时间下降和微生物降解所致。我们的结果表明，如果病毒要进入市政废水处理系统，大多数将分配给活性污泥固体，在中温厌氧消化中幸存下来，并存在于经过处理的生物固体中。

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