Daphnia magna Ecotoxicogenomics Provides Mechanistic Insights into Metal Toxicity

HELEN C. POYNTON; JULIA R. VARSHAVSKY; BONNIE CHANG; GIORGIO CAVIGIOLIO; SARAH CHAN; PATRICIA S. HOLMAN; ALEXANDRE V. LOGUINOV; DARREN J. BAUER; KELLY KOMACHI; ELIZABETH C. THEIL; EDWARD J. PERKINS; OWEN HUGHES; CHRIS D. VULPE

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Daphnia magna Ecotoxicogenomics Provides Mechanistic Insights into Metal Toxicity

机译：大型蚤（Daphnia magna）生态毒理基因组学提供了对金属毒性的机械观察

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Toxicogenomics has provided innovative approaches to chemical screening, risk assessment, and predictive toxicology. If applied to ecotoxicology, genomics tools could greatly enhance the ability to understand the modes of toxicity in environmentally relevant organisms. Daphnia magna, a small aquatic crustacean, is considered a "keystone" species in ecological food webs and is an indicator species for toxicant exposure. Our objective was to demonstrate the potential utility of gene expression profiling in ecotoxicology by identifying novel biomarkers and uncovering potential modes of action in D. magna. Using a custom D. magna cDNA microarray, we identified distinct expression profiles in response to sublethal copper, cadmium, and zinc exposures and discovered specific biomarkers of exposure including two probable metallothioneins, and a ferritin mRNA with a functional IRE. The gene expression patterns support known mechanisms of metal toxicity and reveal novel modes of action including zinc inhibition of chitinase activity. By integrating gene expression profiling into an environmentally important organism, this study provides experimental support for the utility of ecotoxicogenomics.

机译：毒物基因组学为化学筛选，风险评估和预测毒理学提供了创新的方法。如果将其应用于生态毒理学，则基因组学工具可以极大地增强了解与环境有关的生物体内毒害模式的能力。大型水生甲壳动物水蚤（Daphnia magna）被认为是生态食物网中的“基石”物种，并且是有毒物质暴露的指示物种。我们的目标是通过鉴定新颖的生物标志物并揭示大果蝇中的潜在作用方式，来证明基因表达谱在生态毒理学中的潜在用途。使用定制的D. magna cDNA微阵列，我们确定了对亚致死铜，镉和锌暴露的响应不同的表达谱，并发现了特定的生物标志物暴露，包括两种可能的金属硫蛋白和具有功能性IRE的铁蛋白mRNA。基因表达模式支持已知的金属毒性机制，并揭示了新的作用方式，包括锌对几丁质酶活性的抑制作用。通过将基因表达谱整合到对环境重要的生物中，这项研究为生态毒理基因组学的实用性提供了实验支持。

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《Environmental Science & Technology》 |2007年第3期|p.1044-1050|共7页
作者
HELEN C. POYNTON; JULIA R. VARSHAVSKY; BONNIE CHANG; GIORGIO CAVIGIOLIO; SARAH CHAN; PATRICIA S. HOLMAN; ALEXANDRE V. LOGUINOV; DARREN J. BAUER; KELLY KOMACHI; ELIZABETH C. THEIL; EDWARD J. PERKINS; OWEN HUGHES; CHRIS D. VULPE;
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作者单位

Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类环境化学;
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1. Whole-Organism Transcriptomic Analysis Provides Mechanistic Insight into the Acute Toxicity of Emamectin Benzoate in Daphnia magna [J] . You Song, Jan Thomas Rundberget, Linn Mari Evenseth, Environmental Science & Technology . 2016,第21期

机译：全有机体转录组学分析提供了机械学见解，苯甲酸阿米菌素对巨大水蚤的急性毒性。
2. Nanomaterials in the Environment Acquire an “Eco‐Corona” Impacting their Toxicity to Daphnia Magna Daphnia Magna —a Call for Updating Toxicity Testing Policies [J] . Proteomics . 2020,第9期

机译：环境中的纳米材料获得了对Daphnia Magna Daphnia Magna -A呼吁更新毒性测试政策的“生态电晕”。
3. The use of biomarkers in Daphnia magna magna toxicity testing. II. digestive enzyme activity in Daphnia magna Exposed To sublethal concentrations of cadmium, chromium and mercury [J] . W.M.de Coen, C.R.Janssen Chemosphere . 1997,第5期

机译：在大水蚤的毒性测试中使用生物标志物。二。亚致死浓度的镉，铬和汞暴露于大型蚤中的消化酶活性
4. The Acute and Chronic Toxicity of Five Heavy Metals on the Daphnia Magna [C] . Qingjun MENG, Xiangdong LI, Qiyan FENG, The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：水蚤中五种重金属的急性和慢性毒性
5. Bioavailability and toxicity of trace metals to the cladoceran Daphnia magna in relation to cadmium exposure history. [D] . Guan, Rui. 2006

机译：痕量金属对锁骨蚤（Daphnia magna）的生物利用度和毒性与镉暴露史的关系。
6. Daphnia magna’s sense of competition: intra-specific interactions (ISI) alter life history strategies and increase metals toxicity [O] . Kurt A. Gust, Alan J. Kennedy, Nicolas L. Melby, -1

机译：大型蚤（Daphnia magna）的竞争意识：种内相互作用（ISI）改变了生活史策略并增加了金属毒性
7. Daphnia magna Ecotoxicogenomics Provides Mechanistic Insights into Metal Toxicity [O] . -1

机译：Daphnia Magna Ecotoxicogomics将机械洞察力提供成金属毒性
8. Results of a Toxicity Study (Acute Daphnia Magna Test) on Water Flea (Daphnia Magna) with an Intermediate for an Agrochemical Pesticide. [R] . 2015

机译：对水蚤（Daphnia magna）进行毒性研究（急性大型蚤检测）的结果，其中含有农药化学农药中间体。

Daphnia magna Ecotoxicogenomics Provides Mechanistic Insights into Metal Toxicity

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