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首页> 外文期刊>Environmental Science & Technology >Gastrointestinal Microbes Increase Arsenic Bioaccessibility of Ingested Mine Tailings Using the Simulator of the Human Intestinal Microbial Ecosystem
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Gastrointestinal Microbes Increase Arsenic Bioaccessibility of Ingested Mine Tailings Using the Simulator of the Human Intestinal Microbial Ecosystem

机译：胃肠道微生物使用人类肠道微生物生态系统的模拟器增加矿山尾矿的砷生物可及性。

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摘要

It is widely accepted that the use of total metal concentrations in soil overestimates metal risk from human ingestion of contaminated soils. In vitro simulators have been used to estimate the fraction of arsenic present in soil that is bioaccessible in the human digestive track. These approaches assume that the bioaccessible fraction remains constant across soil total metal concentrations and that intestinal microbiota do not contribute to arsenic release. Here, we evaluate both of these assumptions in two size fractions (bulk and < 38 μm) of arsenic-rich mine tailings from the Goldenville, Lower Seal Harbour, and Montague Gold Districts, Nova Scotia. These samples were evaluated using an in vitro gastrointestinal model, the Simulator of the Human Intestinal Ecosystem (SHIME). Arsenic bioaccessibility, which ranged between 2 and 20% in the small intestine and 4 and 70% in the colon, was inversely related to total arsenic concentration in the mine tailings. Additionally, arsenic bioaccessibility was greater in the bulk fraction than in the < 38 μm fraction in the small intestine and colon while colon microbes increased the bioaccessibility of arsenic in mine tailings. These results suggest that the practice of using a constant percent arsenic bioaccessibility across all metal concentrations in risk assessment should be revisited.
机译：人们普遍认为，土壤中总金属浓度的使用会高估人类摄入污染土壤的金属风险。体外模拟器已被用来估算人类消化道中可生物利用的土壤中砷的含量。这些方法假定生物可及部分在土壤总金属浓度范围内保持恒定，并且肠道微生物群不会促进砷释放。在这里，我们用来自新斯科舍省Goldenville，Lower Seal Harbour和Montague Gold Districts的富含砷的矿山尾矿的两个尺寸分数（体积小于38μm）评估了这两个假设。使用体外胃肠道模型，即人类肠道生态系统模拟器（SHIME）对这些样品进行评估。砷的生物可及性，在小肠中为2％至20％，在结肠中为4％至70％，与矿山尾矿中总砷浓度成反比。另外，在小肠和结肠中，大部分中的砷生物可及性高于<38μm部分，而结肠微生物增加了矿山尾矿中砷的生物可及性。这些结果表明，应重新考虑在风险评估中对所有金属浓度使用恒定百分比的砷生物可及性的做法。

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