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首页> 外文期刊>Environmental Science & Technology >Biotransformation of the Polycyclic Musks HHCB and AHTN and Metabolite Formation by Fungi Occurring in Freshwater Environments
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Biotransformation of the Polycyclic Musks HHCB and AHTN and Metabolite Formation by Fungi Occurring in Freshwater Environments

机译：淡水环境中真菌对多环麝香HHCB和AHTN的生物转化和代谢产物形成

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摘要

Micropollutants found in aquatic environments have increasingly raised concerns with respect to their uncertain environmental fate and potentially adverse effects on human health and the environment. The biodegradability of two major representatives of the polycyclic musk fragrances, Galaxolide (HHCB) and Tonalide (AHTN), and the formation of biotransformation metabolites, were investigated with Myrioconium sp. strain UHH 1-13-18-4 and Clavariopsis aquatica, two mitosporic fungi derived from freshwater environments. A particular focus was to assess the effects of extracellular oxidoreductases such as laccases, which are produced by the investigated fungi under certain conditions, on HHCB and AHTN. The fungi converted HHCB and AHTN into various products via initial hydroxylation at different carbon positions. Further metabolism resulted in the subsequent formation of diketone, peroxide, and O-methylated derivatives. Isolated laccases of the investigated fungi were able to oxidize HHCB and AHTN and catalyzed the formation of the metabolite HHCB-lactone from HHCB. At particular environmental situations also specified within the present study, biotransformations catalyzed by fungi occurring in freshwater environments may be considered when addressing the fate of polycyclic musks in freshwater systems and potential biological effects of their degradation metabolites.
机译：在水生环境中发现的微量污染物对其不确定的环境命运以及对人类健康和环境的潜在不利影响日益引起人们的关注。用Myrioconium sp。研究了多环麝香的两种主要代表，Galaxolide（HHCB）和Tonalide（AHTN）的生物降解能力，以及生物转化代谢物的形成。 UHH 1-13-18-4菌株和Clavariopsis aquatica，这两种来自淡水环境的线孢真菌。特别关注的是评估由被研究真菌在一定条件下产生的细胞外氧化还原酶（如漆酶）对HHCB和AHTN的影响。真菌通过在不同碳位置的初始羟基化作用将HHCB和AHTN转化为各种产物。进一步的代谢导致随后形成二酮，过氧化物和O-甲基化衍生物。被研究真菌分离的漆酶能够氧化HHCB和AHTN，并催化HHCB代谢产物HHCB-内酯的形成。在本研究中还指定的特定环境条件下，当解决淡水系统中多环麝香的命运及其降解代谢物的潜在生物学效应时，可以考虑在淡水环境中发生的真菌催化的生物转化。

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