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首页> 外文期刊>Environmental Science & Technology >Exposure to Copper Nanoparticles Causes Gill Injury and Acute Lethality in Zebrafish (Danio rerio)
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Exposure to Copper Nanoparticles Causes Gill Injury and Acute Lethality in Zebrafish (Danio rerio)

机译：铜纳米颗粒的暴露导致斑马鱼（Danio rerio）的ill伤和急性致死性

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Increasing use of metallic nanomaterials is likely to result in release of these particles into aqueous environments; however, it is unclear if these materials present a hazard to aquatic organisms. Because some dissolution of metal particles will occur, it is important to distinguish effects of nanoparticulates from dissolved metals. To address this issue, acute toxicity of soluble copper and 80 nm copper nanoparticle suspensions were examined in zebrafish. The results demonstrate that nanocopper is acutely toxic to zebrafish, with a 48 h LC_(50)concentration of 1.5 mg/L Rapid aggregation of copper nanoparticles occurred after suspension in water, resulting in 50-60% of added mass leaving the water column. While dissolution of particulate copper occurred, it was insufficient to explain the mortality in nanocopper exposures. Histological and biochemical analysis revealed that the gill was the primary target organ for nanocopper. To further investigate the effects of nanocopper on the gill, zebrafish were exposed to 100 μg/L of nanocopper or to the concentration of soluble copper matching that present due to dissolution of the particles. Under these conditions, nanocopper produced different morphological effects and global gene expression patterns in the gill than soluble copper, clearly demonstrating thatthe effects of nanocopper on gill are not mediated solely by dissolution.
机译：越来越多地使用金属纳米材料可能会导致这些颗粒释放到水性环境中。但是，尚不清楚这些物质是否对水生生物构成危害。由于会发生金属颗粒的某些溶解，因此区分纳米颗粒与溶解的金属的影响非常重要。为了解决这个问题，在斑马鱼中研究了可溶性铜和80 nm铜纳米颗粒悬浮液的急性毒性。结果表明，纳米铜对斑马鱼具有剧毒，在48 h LC_（50）浓度为1.5 mg / L悬浮在水中后，铜纳米颗粒迅速聚集，导致离开水柱的附加质量的50-60％。尽管发生了颗粒状铜的溶解，但这不足以解释纳米铜暴露的死亡率。组织学和生化分析表明，g是纳米铜的主要靶器官。为了进一步研究纳米铜对the的影响，将斑马鱼暴露于100μg/ L纳米铜或由于颗粒溶解而存在的可溶性铜匹配浓度。在这些条件下，纳米铜在g中产生的形态学效果和整体基因表达方式与可溶性铜不同，这清楚地表明，纳米铜对g的作用并不仅是通过溶解来介导的。

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