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首页> 外文期刊>Environmental Science & Technology >Demographic and lifestyle factors associated with dioxin-like activity (CALUX-TEQ) in human breast milk in Hong Kong
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Demographic and lifestyle factors associated with dioxin-like activity (CALUX-TEQ) in human breast milk in Hong Kong

机译：香港人母乳中与二恶英样活性（CALUX-TEQ）相关的人口和生活方式因素

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Maternal exposure to dioxins and related compounds before conception may affect the health of the fetus. To identify factors affecting dioxin body load in Hong Kong, in 2002, total dioxin-like activity was estimated in 250 individual milk samples at 2-6 weeks postpartum, from a representative group of primiparous mothers, aged 1842 years (mean 29 +/- 5 years), by a chemically activated luciferase expression (CALUX) bioassay. Associations between the CALUX-TEQ and 20 socio-demographic and dietary variables were examined separately in mothers younger than 30 years (n = 114) and 30 years or older (n = 119), by multiple linear regression analysis. CALUX-TEQ (mean 14.5 +/- 5.8 pg/g fat) significantly increased by 0.4-0.5 pg/g fat for every year of the mother's age. Mothers born in Guangdong province of China had a significantly higher CALUX-TEQ. Higher seafood consumption (older mothers; p = 0.07) and having a female baby (younger mothers; p = 0.002) were associated with a higher maternal CALUX-TEQ level. Age was the strongest factor affecting human dioxin levels in Hong Kong. Birthplace and residence are important indicators of variations in exposure to environmental pollution in the Asia Pacific region. Temporal trends in body loads of dioxins remain to be established and continuous monitoring of dioxins in humans and foods is necessary as a precautionary approach to guide environmental control measures and prevent exposure to infants.
机译：孕妇在受孕前接触二恶英和相关化合物可能会影响胎儿的健康。为了确定影响香港二恶英体重的因素，在2002年，从一组代表性的初产母亲（年龄为1842年）的250个单独的牛奶样本中，估计了产后2-6周的总二恶英样活性（平均29 +/- 5年），通过化学激活的萤光素酶表达（CALUX）生物测定。通过多元线性回归分析，分别对30岁以下（n = 114）和30岁以上（n = 119）的母亲分别检查了CALUX-TEQ与20种社会人口统计学和饮食变量之间的关联。母亲的每一年，CALUX-TEQ（平均14.5 +/- 5.8 pg / g脂肪）显着增加0.4-0.5 pg / g脂肪。在中国广东省出生的母亲的CALUX-TEQ明显更高。较高的海鲜消费量（较大的母亲； p = 0.07）和生有女性的婴儿（较年轻的母亲； p = 0.002）与母亲CALUX-TEQ水平较高相关。年龄是影响香港人体内二恶英水平的最重要因素。出生地和居住地是亚太地区环境污染暴露变化的重要指标。二恶英的体内负荷的时间趋势仍有待确定，人类和食品中二恶英的持续监测是必要的，作为一种预防方法，可指导环境控制措施并防止婴儿接触。

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