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首页> 外文期刊>Environmental Science & Technology >Steroid hormone profiles of urban and tidal rivers using LC/MS/MS equipped with electrospray ionization and atmospheric pressure photoionization sources
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Steroid hormone profiles of urban and tidal rivers using LC/MS/MS equipped with electrospray ionization and atmospheric pressure photoionization sources

机译：使用配备电喷雾电离和大气压光电离源的LC / MS / MS来分析城市和潮汐河流中的类固醇激素谱

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摘要

A highly sensitive and uncomplicated method of analyzing steroidal hormones in river and estuarine water samples was developed using a liquid chromatography tandem mass spectrometer equipped with an electrospray ionization (ESI) source and atmospheric pressure photoionization ( APPI) source. Steroidal hormones included not only estrogen but also androgen and conjugates of these two. APPI displayed greater sensitivity than ESI for most of the unconjugated steroids examined, with very high sensitivity for testosterone and 4-androstene- 3,17-dione in particular. For conjugated hormones, in contrast, ESI was more effective. The method developed was applied to the determination of hormones in the rivers of Osaka City and their estuaries, where the hormones detected were affected by the effluent from municipal wastewater treatment plants (WWTPs), and hormone concentration values were comparable to those reported in previous studies of such effluent. Because of the two-way flow and stagnancy of streams and watercourses, continuous input of steroidal hormones from WWTPs seems to bring about local accumulation. Levels of androgen were 1 order of magnitude lower than those of estrogen. Estrone, estrone 3-sulfate, and 4-androstene- 3,17-dione were detected in almost all water samples, with maxima of 51, 5.1, and 6.4 ng L-1, respectively.
机译：使用配备有电喷雾电离（ESI）源和大气压光电离（APPI）源的液相色谱串联质谱仪，开发了一种高度灵敏，简单的分析河流和河口水样品中类固醇激素的方法。甾体激素不仅包括雌激素，还包括雄激素和这两种的结合物。 APPI对大多数未结合的类固醇显示出比ESI更高的敏感性，特别是对睾丸激素和4-雄甾烯-3,17-二酮的敏感性很高。相反，对于缀合激素，ESI更有效。所开发的方法用于测定大阪市河及其河口中的激素，其中检测到的激素受到市政废水处理厂（WWTP）废水的影响，激素浓度值与以前的研究相当这样的废水。由于溪流和河道的双向流动和停滞，污水处理厂不断输入类固醇激素似乎会引起局部积累。雄激素水平比雌激素水平低1个数量级。在几乎所有的水样中都检测到了雌酮，3-硫酸雌酮和4-雄甾烯酮3,17-二酮，最大值分别为51、5.1和6.4 ng L-1。

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