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Linker-based bio-compatible microemulsions

机译：基于接头的生物相容性微乳液

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In this work we have studied the formulation of biocompatible microemulsions using lecithin as the main surfactant and bio-compatible linker molecules (hexyl polyglucoside as the hydrophilic linker and sorbitan monoleate as the lipophilic linker). These bio-compatible systems are discussed as potential substitutes for chlorinated solvents in dry-cleaning applications and as solvent delivery systems for pharmaceutical applications. Formulation parameters and conditions were evaluated using isopropyl myristate (IPM) as the model oil. It was found that the proposed linker-based formulations were able to form alcoholfree microemulsions while achieving higher solubilization capacity than similar systems reported in the literature. In addition, these lecithin/linker formulations were able to form microemulsions with a wide range of oils, from polar chlorinated hydrocarbons to hydrophobic oils such as squalene. These microemulsions were achieved under isotonic conditions (0.9%NaCI) by only varying the relative proportions of the linkers. The "solvency" power of these bio-compatible formulations was tested for the removal of hexadecane (used as model oil) from cotton fabrics and compared to the solvency power of a typical dry cleaning solvent tetra chloroethylene (PCE). While PCE and the linker-based lecithin formulation removed the same amount of hexadecane at low loading ratios (less than 1% oil volume fraction), at higher loading ratios the linkerbased lecithin formulation retained its oil removal capacity while the efficiency of the PCE.system declined rapidly. These initial results thus demonstrate the remarkable oil solubilization capacity of these bio-compatible linker-based lecithin formulations and illustrate their potential as environmentally friendly replacements for organic solvents.
机译：在这项工作中，我们研究了以卵磷脂为主要表面活性剂和生物相容性连接分子（己基聚葡萄糖苷为亲水性连接体，脱水山梨醇单油酸酯为亲脂性连接体）的生物相容性微乳剂的配方。讨论了这些生物相容性系统，作为干洗应用中氯化溶剂的潜在替代品，以及制药应用中的溶剂输送系统。使用肉豆蔻酸异丙酯（IPM）作为模型油评估配方参数和条件。发现所提出的基于接头的制剂能够形成无醇的微乳液，同时实现比文献中报道的类似系统更高的增溶能力。另外，这些卵磷脂/连接剂制剂能够与多种油形成微乳液，这些油从极性氯化烃到疏水油例如角鲨烯。通过仅改变连接剂的相对比例，在等渗条件下（0.9％NaCl）获得了这些微乳液。测试了这些生物相容制剂的“溶解能力”，以从棉织物中去除十六烷（用作模型油），并将其与典型干洗溶剂四氯乙烯（PCE）的溶解能力进行比较。虽然PCE和基于连接物的卵磷脂制剂在低负载率（小于1％的油体积分数）下去除了相同量的十六烷，但在较高的负载比下，基于连接物的卵磷脂制剂保留了其除油能力，而PCE系统的效率却很高。迅速下降。因此，这些初步结果证明了这些基于生物相容性连接基的卵磷脂制剂具有出色的增油能力，并表明了其作为有机溶剂的环保替代品的潜力。

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