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Protein Nitration by Polluted Air

机译：污染空气中的蛋白质硝化

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摘要

The effects of air pollution on allergic diseases are not yet well-understood. Here, we show that proteins, in particular birch pollen proteins including the allergen Bet v 1, are efficiently nitrated by polluted air. This posttranslational modification of proteins is likely to trigger immune reactions and provides a molecular rationale for the promotion of allergies by traffic-related air pollution. Enzyme immunoassays have been used to determine equivalent degrees of nitration (EDN) for protein samples exposed to urban outdoor air and synthetic gas mixtures. The observed rates of nitration were governed by the abundance of nitrogen oxides and ozone, and concentration levels typical for summer smog conditions led to substantial nitration within a few hours to days (EDN up to 20%). Moreover, nitrated proteins were detected in urban road dust, window dust, and fine air particulate matter (EDN up to 0.1%).
机译：空气污染对过敏性疾病的影响尚未得到很好的理解。在这里，我们显示蛋白质，特别是桦树花粉蛋白质（包括变应原Bet v 1）已被污染空气有效地硝化。蛋白质的这种翻译后修饰可能会触发免疫反应，并为与交通有关的空气污染促进过敏症提供分子基础。酶免疫法已用于确定暴露于城市室外空气和合成气体混合物中的蛋白质样品的等效硝化度（EDN）。观察到的硝化速率受氮氧化物和臭氧的丰度控制，夏季烟雾条件下的典型浓度水平导致在数小时至数天之内发生大量硝化（EDN高达20％）。此外，在城市道路灰尘，窗户灰尘和空气细颗粒物（EDN高达0.1％）中检测到硝酸盐蛋白。

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