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首页> 外文期刊>Environmental Science & Technology >Polycyclic aromatic hydrocarbon biodegradation rates: A structure-based study
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Polycyclic aromatic hydrocarbon biodegradation rates: A structure-based study

机译：多环芳烃的生物降解率：基于结构的研究

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摘要

This study was designed to examine the role of molecular structure in determining the biodegradation rates of polycyclic aromatic hydrocarbons (PAHs). Laboratory experiments were performed in aqueous systems, and data were analyzed in a manner that allowed determination of first-order biodegradation rates independent of bioavailability limitations from physical-chemical processes. An aerobic mixed culture was used, which had been enriched on a broad range of PAHs. The 22 PAHs included in this study ranged in size from two to four rings and included compounds with 5-carbon rings and alkyl substituents. The range of observed biodegradation rates was only 1 order of magnitude, which is much less than that which is typically observed in the field. This supports the findings of other types of studies, which conclude that most of the observed variation in environmental PAH biodegradation rates comes from processes controlling the bioavailability of the compounds and not processes controlling uptake or biotransformation. Rate differences that were observed were attributable either to the presence of a 5-carbon ring or an alkyl substituent in an alpha position. Various molecular descriptors that might be expected to correlate with rate-limiting steps in the biodegradation process were used in an attempt to develop a quantitative structure-activity relationship for the PAH biodegradation rates. No significant correlations were found, but rate limitation from interactions with the relevant enzymes remains a possibility.
机译：这项研究旨在检查分子结构在确定多环芳烃（PAHs）生物降解速率中的作用。在水系统中进行实验室实验，并对数据进行分析的方式可以确定一级生物降解速率，而不受物理化学过程中生物利用度的限制。使用了有氧混合培养物，该培养物富含多种PAH。这项研究中包括的22种PAH的大小为2至4个环，并包括具有5个碳环和烷基取代基的化合物。观察到的生物降解率的范围仅为1个数量级，远小于现场通常观察到的范围。这支持了其他类型研究的发现，这些研究得出的结论是，大多数观察到的环境PAH生物降解速率的变化来自控制化合物生物利用度的过程，而不是控制吸收或生物转化的过程。观察到的速率差异归因于在α位存在5-碳环或烷基取代基。为了建立PAH生物降解速率的定量构效关系，尝试了各种可能与生物降解过程中的限速步骤相关的分子描述子。没有发现明显的相关性，但是与相关酶相互作用的速率限制仍然是可能的。

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