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首页> 外文期刊>Environmental Science & Technology >Estrogenic activity of impurities in industrial grade bisphenol A
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Estrogenic activity of impurities in industrial grade bisphenol A

机译：工业级双酚A中杂质的雌激素活性

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The estrogenicities of 10 compounds found as impurities in industrial grade bisphenol A (BPA) were measured by yeast two-hybrid assays incorporating the human estrogen receptor alpha (hER alpha) or the medaka fish (Oryzias latipes) estrogen receptor alpha (medER alpha). Five impurities showed greater activity than BPA itself in an agonist assay for hERa. p-Cumylphenol, the most active of the impurities in the hER alpha assay, was 12 times as active as BPA. The REC10 (10 % relative effective concentration: 10 % of the activity of 10(-8)M 17 beta-estradiol) was 710 nM. Five impurities showed greater activity than BPA in an agonist assay for medER alpha: 4,4'-(1,3-dimethylbutylidene) bisphenol and 2-(4'-hydroxyphenyl)-2,4,4-trimethylchroman were nearly equipotent and 9 times as active as BPA, and the REC10 values of these compounds in the medERa assay were 280 and 320 nM, respectively. Comparison of the experimentally determined estrogenicities of mixtures of BPA and 4,4'-(1,3-dimethylbutylidene) bisphenol and those calculated by the concentrations addition (CA) method confirmed the suitability of the method for the prediction of the estrogenicities of the mixtures of BPA and its phenolic analogues. The measured estrogenicities of four samples of industrial grade BPA and laboratory grade (pure) BPA were not significantly different in either the hER alpha assay or the medER alpha assay (p > 0.05 in each case). We conclude that the impurities in industrial grade BPA, although some are of much higher estrogenic activity than BPA itself, do not significantly increase the estrogenicity of the industrial compound and therefore do not increase possible adverse health effects from such activity.
机译：通过酵母双杂交测定法测定了工业级双酚A（BPA）中作为杂质的10种化合物的雌激素性，该方法采用了人类雌激素受体α（hER alpha）或鱼（Oryzias latipes）雌激素受体α（medER alpha）。在hERa的激动剂分析中，五种杂质显示出比BPA本身更大的活性。对-枯酚是hER alpha分析中最活跃的杂质，其活性是BPA的12倍。 REC10（10％相对有效浓度：10（-8）M 17β-雌二醇活性的10％）为710 nM。在medERα的激动剂分析中，五种杂质的活性高于BPA：4,4'-（1,3-二甲基丁烯）双酚和2-（4'-羟基苯基）-2,4,4-三甲基苯并[9]活性是BPA的两倍，而这些化合物在MEDERa分析中的REC10值分别为280和320 nM。实验确定的BPA和4,4'-（1,3-二甲基丁烯）双酚混合物的雌激素性与通过浓度加成法（CA）计算的雌激素性的比较证实了该方法适用于预测混合物的雌激素性BPA及其酚类似物。在hER alpha分析或medER alpha分析中，四种工业级BPA和实验室级（纯）BPA样品的雌激素测量值均无显着差异（每种情况下p> 0.05）。我们得出的结论是，尽管工业级BPA中的某些杂质的雌激素活性比BPA本身高得多，但它们并未显着提高工业化合物的雌激素性，因此不会增加此类活性可能对健康造成的不利影响。

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