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首页> 外文期刊>Environmental Science & Technology >Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations
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Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations

机译：高氯酸盐在环境相关浓度下影响东部蚊子（Gambusia holbrooki）的甲状腺功能

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摘要

The purpose of this study was to determine the effects of perchlorate on thyroid function in mosquitofish. Adult mosquitofish were exposed to 0, 0.1, 1, 10, 100, and 1000 mg/L sodium perchlorate for 2, 10, and 30 d. Whole body thyroxin (T-4) content and histological assessment of thyroid follicles (e.g., follicular epithelial height, hyperplasia, hypertrophy, and colloid depletion) were used to gauge alterations in thyroid function. Follicular epithelial cell height, hyperplasia, and hypertrophy increased with increasing perchlorate concentration, especially in fish exposed for 30 d, and these effects were statistically significantly different from control at concentrations as low as 0.1 mg/L (nominal concentration). The percent occurrence of follicles with depleted colloid decreased with increasing perchlorate concentration, which is contrary to what is expected with thyroid inhibition. There also was a decrease in whole body T4 concentration in fish exposed to perchlorate for 30 d, but clear dose-response relationships were less evident for whole body T4 than for histopathological endpoints. In conclusion, thyroid histopathology provides a sensitive biomarker for thyroid endocrine disruption at environmentally relevant concentrations of sodium perchlorate, and whole body T4 is a less sensitive indicator of perchlorate exposure than is histopathology.
机译：这项研究的目的是确定高氯酸盐对蚊鱼甲状腺功能的影响。将成年蚊鱼暴露于0、0.1、1、10、100和1000 mg / L高氯酸钠中2、10和30 d。全身甲状腺素（T-4）含量和甲状腺滤泡的组织学评估（例如滤泡上皮高度，增生，肥大和胶体耗竭）用于评估甲状腺功能的变化。滤泡上皮细胞高度，增生和肥大随着高氯酸盐浓度的增加而增加，特别是在暴露30 d的鱼中，这些影响在低至0.1 mg / L（标称浓度）的浓度下与对照组相比有统计学差异。随着高氯酸盐浓度的增加，具有减少的胶体的卵泡的发生百分比降低，这与甲状腺抑制所预期的相反。暴露于高氯酸盐30 d的鱼体内的全身T4浓度也有所降低，但是与组织病理学终点相比，全身T4的明显的剂量反应关系不那么明显。总之，在与环境有关的高氯酸钠浓度下，甲状腺组织病理学为甲状腺内分泌破坏提供了敏感的生物标志物，而与组织病理学相比，全身T4对高氯酸盐暴露的敏感性较低。

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