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首页> 外文期刊>Environmental Science & Technology >Bioaccumulation, Biotransformation, and Biochemical Effects of Brominated Diphenyl Ethers in Juvenile Lake Trout (Salvelinus namaycush)
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Bioaccumulation, Biotransformation, and Biochemical Effects of Brominated Diphenyl Ethers in Juvenile Lake Trout (Salvelinus namaycush)

机译：少年鳟鱼中的溴化二苯醚的生物富集，生物转化和生化作用（Salvelinus namaycush）

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Juvenile lake trout (Salvelinus namaycush) were exposed to three dietary concentrations (0, ～2.5, and ～25 ng/g per BDE congener) of 13 BDE congeners (3-10 Br atoms) in the laboratory for 56 days, followed by 112 days of clean food, to examine bioaccumulation parameters and potential biochemical effects. The bioaccumulation of BDEs by the trout was highly influenced by biotransformation, via debromination, which resulted in bioaccumulation parameters thatwere much different than would be expected based on studies of chlorinated organic compounds (e.g., PCBs). Half-lives (t{sub}(1/2)'s) for some BDE congeners (e.g., BDE-85 and -190) were much lower than expected based on their K{sub}(OW), which was likely due to biotransformation, whereas t{sub}(1/2)'s of other BDE congeners (e.g., BDE-66, -77, -153, and -154) were much longer than anticipated based on K{sub}(ow). This was likely because the metabolites of BDE formed via debromination had the same chemical structure of these BDE congeners, which supplemented measured concentrations. The detection of three BDE congeners (an unknown penta, BDE-140, and an unknown hexa) in the fish that were not present in the food or in the control fish provide further evidence for the debromination of BDEs. Half-lives of BDEs ranged from 38±9 to 346±173 days and biomagnification factors ranged from 1.6 (BDE-190) to 45.9 (BDE-100), but these bioaccumulation parameters need to be viewed with caution because they were highly influenced by debromination and relative abundance of individual BDEs thatthe fish were exposed to. CYP 1A enzyme activity, measured as EROD, and free tri-iodothyronine (T3) concentrations in the plasma of lake trout varied significantly throughout the experiment but were not related to BDE exposure. In contrast, plasma levels of thyroxine levels (T4) were lower in both groups of PBDE-exposed fish compared with control fish after 56 days of exposure, and after 168 days in the high dose, suggesting that PBDEs may influence thyroid homeostasis at levels that are higher than what is normally found in the environment.
机译：在实验室中，将幼稚湖鳟鱼（Salvelinus namaycush）暴露于13种BDE同系物（3-10 Br原子）的三种饮食浓度（每个BDE同系物分别为0，〜2.5和〜25 ng / g），然后暴露112天天的清洁食品，以检查生物蓄积参数和潜在的生化影响。鳟鱼对BDEs的生物积累受到脱溴作用的生物转化的影响很大，这导致生物积累参数与根据氯化有机化合物（例如PCBs）的研究预期的参数有很大不同。某些BDE同系物（例如BDE-85和-190）的半衰期（t {sub}（1/2）'s比根据其K {sub}（OW）所预期的要低得多。进行生物转化，而其他BDE同系物（例如BDE-66，-77，-153和-154）的t {sub}（1/2）则比基于K {sub}（ow）的预期长得多。这可能是因为通过脱溴作用形成的BDE代谢物具有与这些BDE同系物相同的化学结构，从而补充了所测量的浓度。在食物或对照鱼中不存在的鱼类中检测到三种BDE同源物（未知五价态，BDE-140和未知六价态）为BDE的脱溴提供了进一步的证据。 BDEs的半衰期为38±9至346±173天，生物放大系数为1.6（BDE-190）至45.9（BDE-100），但这些生物蓄积参数受到谨慎影响，因为它们受到鱼类所接触的多溴二苯醚的脱溴和相对丰度。在整个实验中，湖鳟血浆中的CYP 1A酶活性（以EROD表示）和游离三碘甲状腺素（T3）浓度变化显着，但与BDE暴露无关。相反，暴露于56天后和高剂量暴露168天后，两组PBDEs暴露的鱼类血浆甲状腺素水平（T4）均低于对照鱼，这表明PBDEs可能影响甲状腺稳态。高于环境中的正常水平。

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