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A STATUS REPORT ON FIELD-PORTABLE IMMUNOASSAY

机译:关于现场便携式免疫测定的状态报告

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摘要

The development of environmental immu-nochemical technologies and their growing acceptance within the regulatory community have revolutionized many field and laboratory analyses. Beginning in the 1980s, environmental scientists adapted methods that had earlier resulted in a Nobel prize for ra-dioimmunoassay (1). Pesticide analytical chemists, recognizing the shortcomings of gas chromatogra-phy (GC) for some applications, championed the use of immunoassays. Since this pioneering work, im-munoassays have been developed for scores of contaminants in a variety of matrices and for a multitude of monitoring applications. There are many current challenges in the research and application of immunoassay methods. A primary goal is to advance immunoassays to the next stage of environmental analytical acceptance by involving chemists in the development of quantitative methods. Analytical chemists are beginning to integrate immunochemical methods such as immunoassay as a detector for microbore high-performance liquid chromatography; immunoaffinity chro-matography is being integrated with standard detection procedures such as mass spectrometry (MS). These tandem techniques result in more versatile methods for samples of environmental importance.
机译:环境免疫化学技术的发展以及它们在监管界的日益接受,彻底改变了许多现场和实验室分析方法。从1980年代开始,环境科学家采用了较早获得诺贝尔奖的放射免疫测定法(1)。农药分析化学家认识到气相色谱法(GC)在某些应用中的缺点,因此提倡使用免疫分析法。自从这项开创性的工作以来,已经开发了免疫分析法,用于多种基质中的多种污染物以及多种监测应用。在免疫测定方法的研究和应用中当前存在许多挑战。一个主要目标是通过让化学家参与定量方法的开发,将免疫测定推进到环境分析接受的下一阶段。分析化学家开始整合免疫化学方法,例如将免疫分析法作为微孔高效液相色谱检测器。免疫亲和色谱已与标准检测程序(例如质谱(MS))集成在一起。这些串联技术为具有环境重要性的样品提供了更加通用的方法。

著录项

  • 来源
    《Environmental Science & Technology》 |1995年第7期|p.312A-317A|共6页
  • 作者单位

    EPA Exposure Research Laboratory, Characterization Research Division-Las Vegas;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 环境化学;
  • 关键词

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