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首页> 外文期刊>Environmental toxicology and pharmacology >Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin
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Inhibition of diethylnitrosamine-induced liver cancer in rats by Rhizoma paridis saponin

机译：鼠李总皂甙对二乙基亚硝胺诱导的大鼠肝癌的抑制作用

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摘要

Rhizoma Paridis saponin (RPS) had been regarded as the main active components responsible for the anti-tumor effects of the herb Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. In the present research, we set up a rat model of diethylnitrosamine (DEN) induced hepatoma to evaluate antitumor effect of RPS. After 20 weeks treatment, rats were sacrificed to perform histopathological examinations, liver function tests, oxidative stress assays and so forth. As a result, DEN-induced hepatoma formation. RPS alleviated levels of liver injury through inhibiting liver tissues of malondialdehyde (MDA) and nitric oxide (NO) formation, increasing superoxide dismutases (SOD) production, and up-regulating expression of GST-α/μ/π in DEN-induced rats. All in all, RPS would be a potent agent inhibiting chemically induced liver cancer in the prospective application.
机译：根茎皂苷（RPS）被认为是负责植物巴黎七叶皂甙var的抗肿瘤作用的主要活性成分。云南（法国）手。在本研究中，我们建立了大鼠二乙基亚硝胺（DEN）诱导的肝癌模型，以评估RPS的抗肿瘤作用。治疗20周后，处死大鼠以进行组织病理学检查，肝功能检查，氧化应激测定等。结果，DEN诱导肝癌形成。 RPS通过抑制丙二醛（MDA）和一氧化氮（NO）的肝脏组织，增加超氧化物歧化酶（SOD）的产生以及上调DEN诱导的大鼠中GST-α/μ/π的表达来减轻肝脏损伤的程度。总而言之，RPS在前瞻性应用中将是抑制化学诱导肝癌的有效药物。

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  • 来源
    《Environmental toxicology and pharmacology》 |2016年第9期|103-109|共7页
  • 作者

    Jing Liu; Shuli Man; Jing Li; Yang Zhang; Xin Meng; Wenyuan Gao;

  • 作者单位

    Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China,Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China;

    Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China,Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China;

    Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China;

    Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China;

    Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China;

    Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China;

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  • 正文语种 eng
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  • 关键词

    Hpatoma; Rhizoma paridis saponin; Oxidative stress; Diethylnitrosamine;

    机译：肝癌;根茎皂苷;氧化应激二乙基亚硝胺;

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