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首页> 外文期刊>Environmental toxicology and pharmacology >Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: Glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine
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Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: Glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine

机译：大鼠亚致命性饮用水中除草剂草甘膦的亚致死作用：谷胱甘肽转移酶活性，肝，肾和小肠中谷胱甘肽还原酶水平和脂质过氧化作用

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摘要

Glyphosate (GLP), the active ingredient of many weed killing formulations, is a broad spectrum herbicide compound. Wistar rats were exposed during 30 or 90 days to the highest level (0.7 mg/L) of GLP allowed in water for human consumption (US EPA, 2011) and a 10-fold higher concentration (7 mg/L). The low levels of exposure to the herbicide did not produce histomorphological changes. The production of TBARS was similar or tended to be lower compared to control animals not exposed to the herbicide. In rats exposed to GLP, increased levels of reduced glutathione (GSH) and enhanced glutathione peroxidase (GPx) activity may act as a protective mechanism against possible detrimental effects of the herbicide. Overall, this work showed certain biochemical modifications, even at 3-20-fold lower doses of GLP than the oral reference dose of 2 mg/kg/day (US EPA, 1993). The toxicological significance of these findings remains to be clarified.
机译：草甘膦（GLP）是许多除草配方中的活性成分，是一种广谱除草剂化合物。 Wistar大鼠在30或90天内暴露于水中允许人类食用的GLP最高水平（0.7 mg / L）（美国EPA，2011）和10倍更高的浓度（7 mg / L）。低水平的除草剂暴露不会产生组织形态变化。与未暴露于除草剂的对照动物相比，TBARS的产量相似或趋于降低。在暴露于GLP的大鼠中，降低的谷胱甘肽（GSH）和增强的谷胱甘肽过氧化物酶（GPx）活性的水平升高可能充当针对除草剂可能有害作用的保护机制。总的来说，这项工作显示出某些生化修饰，即使GLP剂量比口服参考剂量2 mg / kg / day低3-20倍（US EPA，1993）。这些发现的毒理学意义尚待阐明。

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  • 来源
    《Environmental toxicology and pharmacology》 |2012年第3期|811-818|共8页
  • 作者

    K. Larsen; R. Najle; A. Lifschitz; G. Virkel;

  • 作者单位

    Laboratorio de Biologfa y Ecotoxicologia, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina,Laboratorio de Farmacologia, Facultad de Ciencias Veterinarias (UNCPBA), Centra de Investigation Veterinaria Tandil(CIVETAN-CONICET), Argentina,Laboratorio de Biologia y Ecotoxicologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centra de la Provincia de Buenos Aires, Campus Universitario, (7000) Tandil, Argentina;

    Laboratorio de Biologfa y Ecotoxicologia, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina;

    Laboratorio de Farmacologia, Facultad de Ciencias Veterinarias (UNCPBA), Centra de Investigation Veterinaria Tandil(CIVETAN-CONICET), Argentina;

    Laboratorio de Farmacologia, Facultad de Ciencias Veterinarias (UNCPBA), Centra de Investigation Veterinaria Tandil(CIVETAN-CONICET), Argentina;

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  • 正文语种 eng
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  • 关键词

    glyphosate; glutathione transferases; lipid peroxidation; rats;

    机译：草甘膦谷胱甘肽转移酶;脂质过氧化老鼠;

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