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首页> 外文期刊>Environmental toxicology and chemistry >Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas)
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Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas)

机译：抗菌污染物三氯卡班以及与雄激素17-群勃龙的共同暴露对on鱼head鱼生殖功能和卵巢转录组的影响（Pimephales promelas）

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摘要

Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endocrine disruptor 17-trenbolone (TRB) on fish reproductive function. Adult Pimephales promelas were continuously exposed to either 1 mu g TCC/L or 5 mu g TCC/L, to 0.5 mu g TRB/L, or to a mixture (MIX) of 5 mu g TCC/L and 0.5 mu g TRB/L for 22 d, and a variety of reproductive and endocrine-related endpoints were examined. Cumulative fecundity was significantly reduced in fathead minnows exposed to TRB, MIX, or 5 mu g TCC/L. Exposure to 1 mu g TCC/L had no effect on reproduction. In general, both TRB and MIX treatments caused similar physiological effects, evoking significant reductions in female plasma vitellogenin, estradiol, and testosterone, and significant increases in male plasma estradiol. Based on analysis of the ovarian transcriptome, there were potential pathway impacts that were common to both TRB- and TCC-containing treatment groups. In most cases, however, those pathways were more plausibly linked to differences in reproductive status than to androgen-specific functions. Overall, TCC was reproductively toxic to fish at concentrations at or near those that have been measured in surface water. There was little evidence that TCC elicits reproductive toxicity through a specific mode of endocrine or reproductive action, nor that it could augment the androgenic effects of TRB. Nonetheless, the relatively small margin of safety between some measured environmental concentrations and effect concentrations suggests that concern is warranted. Environ Toxicol Chem 2017;36:231-242. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
机译：三氯卡班（TCC）是一种在地表水中常规检测到的抗菌剂，据推测与脊椎动物的内分泌系统相互作用。本研究检查了单独的TCC以及与模型内分泌干扰物17-群勃龙（TRB）组合对鱼类生殖功能的影响。将成年的果蝇头素连续暴露于1μgTCC / L或5μgTCC / L，0.5μgTRB / L或5μgTCC / L和0.5μgTRB /的混合物（MIX）中L持续22天，并检查了各种生殖和内分泌相关终点。暴露于TRB，MIX或5μg TCC / L的黑头min鱼的累积繁殖力显着降低。暴露于1微克TCC / L对繁殖没有影响。一般而言，TRB和MIX疗法均会产生相似的生理效应，引起女性血浆卵黄蛋白原，雌二醇和睾丸激素显着减少，而男性血浆雌二醇显着增加。基于对卵巢转录组的分析，存在潜在的途径影响，这对于包含TRB和TCC的治疗组都是普遍的。然而，在大多数情况下，这些途径与生殖状态差异的联系似乎比与雄激素特异性功能的联系更为合理。总的来说，TCC对鱼类的生殖毒性达到或接近地表水中所测浓度。几乎没有证据表明TCC通过内分泌或生殖作用的特定方式引起生殖毒性，也没有增加TRB的雄激素作用。但是，在某些测得的环境浓度和影响浓度之间相对较小的安全裕度表明值得关注。 Environ Toxicol Chem 2017; 36：231-242。代表SETAC发布了2016年Wiley Periodicals Inc.。本文是美国政府的工作，因此，它属于美国的公共领域。

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