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首页> 外文期刊>Environmental toxicology and chemistry >Effect of age on acute toxicity of cadmium, copper, nickel, and zinc in individual-metal exposures to Daphnia magna neonates
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Effect of age on acute toxicity of cadmium, copper, nickel, and zinc in individual-metal exposures to Daphnia magna neonates

机译：年龄对大水蚤新生儿单金属暴露中镉，铜，镍和锌急性毒性的影响

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In previous studies, variability was high among replicate acute cadmium (Cd) Daphnia magna lethality tests (e.g., >10-fold range of median effect concentrations [EC50s]), less among zinc (Zn) tests, and relatively low for copper (Cu) and nickel (Ni) tests. Although the US Environmental Protection Agency's (USEPA's) protocol includes starting toxicity tests with neonates less than 24h old, the authors hypothesized that age-related differences in sensitivity to metals might occur even within that relatively narrow age range. Daphnia magna neonates were collected during 3 age windows (0-4h, 10-14h, and 20-24h old) and immediately exposed to each of the 4 metals for 48h using the standard USEPA protocol. In repeated sets of tests during different weeks, the Cd EC50 of the youngest neonates was approximately 10-fold greater than the EC50 of the oldest neonates (i.e., Cd was less toxic to the youngest neonates) and the EC50 of neonates aged 10h to 14h was intermediate. Age-related differences were negligible in Cu, Ni, and Zn tests. Therefore, variability in toxicity of Cd may partly be caused by temporal variability in neonate age at the start of toxicity tests. Decreasing the age range of D. magna used in toxicity tests could help to improve the accuracy and precision of toxicity models, particularly for metal mixtures. Environ Toxicol Chem 2017;36:113-119. (c) 2016 SETAC
机译：在先前的研究中，重复性急性镉（Cd）蚤（Daphnia magna）致死性测试中的变异性较高（例如，中位效应浓度[EC50s]的> 10倍范围），锌（Zn）测试中的变异性较小，而铜（Cu ）和镍（Ni）测试。尽管美国环境保护局（USEPA）的协议包括对年龄小于24h的新生儿进行毒性试验，但作者们假设即使在相对较窄的年龄范围内，对金属的敏感性也会出现与年龄相关的差异。在3个年龄窗（0-4h，10-14h和20-24h大）内收集大型水蚤新生儿，并立即使用标准USEPA规程将其暴露于4种金属中的48h。在不同星期的重复测试中，最年轻的婴儿的Cd EC50大约是最年长的婴儿的EC50（即Cd对最年轻的婴儿毒性较小）和10h至14h的新生儿的EC50。是中间的。在铜，镍和锌测试中，与年龄相关的差异可以忽略不计。因此，镉毒性的变异性可能部分由毒性试验开始时新生儿的时间变异性引起。减少毒性试验中使用的D. magna的年龄范围可以帮助提高毒性模型的准确性和精密度，尤其是对于金属混合物。 Environ Toxicol Chem 2017; 36：113-119。 （c）2016年SETAC

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