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首页> 外文期刊>Environmental toxicology and chemistry >EVALUATING THE CREDIBILITY OF HISTOPATHOLOGY DATA IN ENVIRONMENTAL ENDOCRINE TOXICITY STUDIES
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EVALUATING THE CREDIBILITY OF HISTOPATHOLOGY DATA IN ENVIRONMENTAL ENDOCRINE TOXICITY STUDIES

机译：在环境内分泌毒性研究中评估组织学数据的可信度

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Agencies responsible for environmental protection are tasked with developing regulatory guidance that is based on the best available scientific evidence. Histopathology is a common endpoint in toxicologic bioassays; however, because of the subjective nature of this endpoint, and the advanced level of specialized training required for its effective utilization, the reliability of histopathology data can be inconsistent. Consequently, mechanisms for evaluating such data on a case-by-case basis are needed. The purposes of the present review are to describe a methodology that can be used to evaluate the credibility of histopathology findings and to discuss the results of such assessments as applied to real-world data collected from the scientific literature. A key outcome of these efforts was the finding that only 54% of the studies examined contained histopathology data that were considered to be either highly credible or credible, whereas data in 46% of those studies were of equivocal, dubious, or no credibility. In addition, the results indicated that the quality of the data examined tended to decline during the past 15 yr. The ultimate goals of the present review are to draw attention to reliability issues that can affect histopathology results, provide recommendations to improve the quality of this endpoint, and suggest an approach for the expeditious and judicious use of histopathology data in the weight-of-evidence determinations required for hazard and/or risk assessment. This exercise was conducted initially as part of a SETAC Pellston Workshop (TM) entitled "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals (EHRA): Developing Technical Guidance Based on Case Studies to Support Decision Making" that was held in Pensacola, Florida (USA) from 31 January to 5 February 2016. (C) 2016 SETAC
机译：负责环境保护的机构负责根据最有效的科学证据制定监管指南。在毒理学生物测定中，组织病理学是一个共同的终点。但是，由于该终点的主观性质以及有效利用该终点所需要的专门训练的高级水平，组织病理学数据的可靠性可能会不一致。因此，需要用于逐案评估此类数据的机制。本综述的目的是描述一种可用于评估组织病理学结果可信度的方法，并讨论可用于从科学文献中收集的真实数据的评估结果。这些努力的关键成果是发现，只有54％的研究包含被认为是高度可信或可信的组织病理学数据，而这些研究中有46％的数据却是模棱两可，可疑或没有可信度。此外，结果表明，在过去的15年中，所检查数据的质量趋于下降。本文的最终目的是引起人们对可能影响组织病理学结果的可靠性问题的关注，提出提高该终点质量的建议，并提出一种在证据权重中迅速，明智地使用组织病理学数据的方法。危害和/或风险评估所需的确定。该练习最初是在SETAC Pellston研讨会（TM）的一部分中进行的，该研讨会的标题为“内分泌活性化学品的环境危害和风险评估方法（EHRA）：基于案例研究制定技术指导以支持决策制定”， 2016年1月31日至2月5日在美国佛罗里达州（C）2016 SETAC

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