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首页> 外文期刊>Environmental toxicology and chemistry >CHARACTERIZATION OF QUALITY OF SEDIMENTS FROM PARANAGUA A BAY (BRAZIL) BY COMBINED IN VITRO BIOASSAYS AND CHEMICAL ANALYSES
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CHARACTERIZATION OF QUALITY OF SEDIMENTS FROM PARANAGUA A BAY (BRAZIL) BY COMBINED IN VITRO BIOASSAYS AND CHEMICAL ANALYSES

机译：体外生物测定和化学分析相结合的方法来鉴定巴西蛙蛙的沉积物质量

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摘要

The present study characterizes the quality of sediments from the Paranagua Estuarine Complex (South Brazil). Polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) were determined in sediment samples together with a series of different in vitro bioassays. The fish hepatoma cell line (PLHC-1) was used to determine the presence of cytotoxic compounds and CYP1A- and oxidative stress-inducing agents in sediment extracts. Ovarian microsomal fractions from sea bass (Dicentrarchus labrax) were used to detect the presence of endocrine disrupters that interfered with the synthesis of estrogens (ovarian CYP19). Despite the relatively low levels of pollutants and no evidence of negative effects based on guideline levels, sediments collected close to harbors were enriched with CYP1A-inducing agents and they showed higher cytotoxicity. In contrast, sediments from internal areas inhibited CYP19 activity, which suggests the presence of endocrine disrupters at these sites. Overall, the selected bioassays and the chemistry data led to the identification of potentially impacted areas along the Paranagua Estuarine Complex that would require further action to improve their environmental quality. (C) 2016 SETAC
机译：本研究表征了巴拉那瓜河口综合体（巴西南部）的沉积物质量。在沉积物样品中测定了多环芳烃（PAH），多氯联苯（PCB）和有机氯农药（OCP）以及一系列不同的体外生物测定。鱼肝癌细胞系（PLHC-1）用于确定沉积物提取物中是否存在细胞毒性化合物以及CYP1A和氧化应激诱导剂。来自鲈鱼（Dicentrarchus labrax）的卵巢微粒体级分用于检测干扰雌激素合成的内分泌干扰物（卵巢CYP19）的存在。尽管污染物水平相对较低并且没有根据指导方针水平产生负面影响的证据，但靠近港口收集的沉积物富含CYP1A诱导剂，并显示出更高的细胞毒性。相反，内部区域的沉积物抑制了CYP19的活性，这表明在这些位点存在内分泌干扰物。总体而言，选定的生物测定法和化学数据可确定沿巴拉那瓜河口综合设施的潜在影响区域，这将需要采取进一步行动来改善其环境质量。 （C）2016年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第7期|1811-1819|共9页
  • 作者

    Rizzi Juliane; Perez-Albaladejo Elisabet; Fernandes Denise; Contreras Javier; Froehner Sandro; Portez Cinta;

  • 作者单位

    Univ Fed Parana, Water Resources & Environm Engn Grad Program, Curitiba, Parana, Brazil|Spanish Council Sci Res, Dept Environm Chem, Inst Environm Assessment & Water Res, Barcelona, Catalunya, Spain;

    Spanish Council Sci Res, Dept Environm Chem, Inst Environm Assessment & Water Res, Barcelona, Catalunya, Spain;

    Spanish Council Sci Res, Dept Environm Chem, Inst Environm Assessment & Water Res, Barcelona, Catalunya, Spain;

    Spanish Council Sci Res, Dept Environm Chem, Inst Environm Assessment & Water Res, Barcelona, Catalunya, Spain;

    Univ Fed Parana, Water Resources & Environm Engn Grad Program, Curitiba, Parana, Brazil|Univ Fed Parana, Dept Environm Engn, Curitiba, Parana, Brazil;

    Spanish Council Sci Res, Dept Environm Chem, Inst Environm Assessment & Water Res, Barcelona, Catalunya, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Sediment contamination; Organic pollutants; In vitro bioassays; Endocrine disruption; Biomonitoring;

    机译：沉积物污染;有机污染物;体外生物测定;内分泌干扰;生物监测;

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