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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF METALS ON ENANTIOSELECTIVE TOXICITY AND BIOTRANSFORMATION OF CIS-BIFENTHRIN IN ZEBRAFISH
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EFFECTS OF METALS ON ENANTIOSELECTIVE TOXICITY AND BIOTRANSFORMATION OF CIS-BIFENTHRIN IN ZEBRAFISH

机译：金属对斑马鱼中CIS-双联苯胺的对映选择性毒性和生物转化的影响

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摘要

Co-occurrence of pyrethroids and metals in watersheds previously has been reported to pose great risk to aquatic species. Pyrethroids are a class of chiral insecticides that have been shown to have enantioselective toxicity and biotransformation. However, the influence of metals on enantioselectivity of pyrethroids has not yet been evaluated. In the present study, the effects of cadmium (Cd), copper (Cu), and lead (Pb) on the enantioselective toxicity and metabolism of cis-bifenthrin (cis-BF) were investigated in zebrafish at environmentally relevant concentrations. The addition of Cd, Cu, or Pb significantly increased the mortality of zebrafish in racemate and R-enantiomer of cis-BF-treated groups. In rac-cis-BF-or 1R-cis-BF-treated groups, the addition of Cd, Cu, or Pb caused a decrease in enantiomeric fraction (EF) and an increased ratio of R-enantiomer residues in zebrafish. In 1S-cis-BF-treated groups, coexposure to Cd led to a lower EF and decreased residue levels of S-enantiomer. In addition, coexposure to the 3 metals resulted in different biodegradation characteristics of each enantiomer accompanied with differential changes in the expression of cytochrome P450 (CYP)1, CYP2, and CYP3 genes, which might be responsible for the enantioselective biodegradation of cis-BF in zebrafish. These results suggest that the influence of coexistent metals should be considered in the ecological risk assessment of chiral pyrethroids in aquatic environments. Environ Toxicol Chem 2017; 36: 2139-2146. (C) 2017 SETAC
机译：据报道，以前在流域中同时存在拟除虫菊酯和金属会给水生生物带来巨大风险。拟除虫菊酯是一类手性杀虫剂，已显示具有对映选择性毒性和生物转化作用。但是，尚未评估金属对拟除虫菊酯对映选择性的影响。在本研究中，研究了在环境相关浓度下，斑马鱼中镉（Cd），铜（Cu）和铅（Pb）对顺式联苯菊酯（cis-BF）的对映选择性毒性和代谢的影响。 Cd，Cu或Pb的添加显着增加了斑马鱼在顺式BF处理组的外消旋物和R对映体中的死亡率。在rac-顺式-BF-或1R-顺式-BF处理的组中，添加Cd，Cu或Pb导致斑马鱼中对映体分数（EF）降低和R-对映体残基比率增加。在1S-顺式-BF处理组中，与Cd的共同暴露导致EF降低和S-对映异构体的残留水平降低。此外，同时暴露于这三种金属会导致每种对映异构体的生物降解特性不同，并伴随着细胞色素P450（CYP）1，CYP2和CYP3基因表达的差异性变化，这可能是导致顺式BF对映体选择性生物降解的原因。斑马鱼。这些结果表明，在水生环境中手性拟除虫菊酯的生态风险评估中应考虑共存金属的影响。环境毒性化学2017; 36：2139-2146。 （C）2017年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第8期|1-16|共16页
  • 作者

    Yang Ye; Ji Dapeng; Huang Xin; Zhang Jianyun; Liu Jing;

  • 作者单位

    Zhejiang Univ, Coll Environm & Resource Sci, Minist Educ, Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou, Zhejiang, Peoples R China|Zhejiang Acad Med Sci, Inst Hyg, Hangzhou, Zhejiang, Peoples R China;

    Zhejiang Univ, Coll Environm & Resource Sci, Minist Educ, Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou, Zhejiang, Peoples R China;

    Zhejiang Univ, Coll Environm & Resource Sci, Minist Educ, Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou, Zhejiang, Peoples R China;

    Zhejiang Univ, Coll Environm & Resource Sci, Minist Educ, Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou, Zhejiang, Peoples R China;

    Zhejiang Univ, Coll Environm & Resource Sci, Minist Educ, Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou, Zhejiang, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Pyrethroids; Metals; Enantioselective toxicity; Enantioselective biotransformation; Zebrafish;

    机译：拟除虫菊酯;金属;对映选择性毒性;对映选择性生物转化;斑马鱼;

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