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首页> 外文期刊>Environmental toxicology and chemistry >PREDICTIVE META-REGRESSIONS RELATING MERCURY TISSUE CONCENTRATIONS OF FRESHWATER PISCIVOROUS MAMMALS
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PREDICTIVE META-REGRESSIONS RELATING MERCURY TISSUE CONCENTRATIONS OF FRESHWATER PISCIVOROUS MAMMALS

机译：关于淡水食源性哺乳动物汞组织浓度的预测性元回归

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摘要

Mercury (Hg) is a pollutant of global concern. Sentinel species such as river otter (Lontra canadensis) and mink (Neovison vison) are often used to monitor environmental concentrations in freshwater ecosystems. Tissue total Hg (THg) concentrations are frequently used as biomarkers of exposure. However, there is no comprehensive model relating Hg tissue concentrations in different tissues, making interstudy comparisons challenging. Our objective was to establish conversion factors relating fur, brain, liver, kidney, and muscle THg concentrations using mean concentrations and standard errors reported in the literature. We used data from more than 6000 samples, pooled across 16 studies and 96 sampling sites in North America and Europe. Sixteen regressions were derived for the river otter and mink models, which were statistically significant at a 95% confidence interval and yielded high explained variances. The models were validated using an external data set of individually measured THg tissue concentrations. The validated conversions were used to evaluate the current fur Hg screening guidelines of 20 mu g/g and 30 mu g/g. At both of these fur concentrations, brain concentrations are of concern for altering brain neurochemistry. Wesuggest a more conservative fur Hg screening guideline of 15 mu g/g to protect sensitive furbearers. The conversion factors can be used to predict internal organ THg concentrations from fur measurements, eliminating the need for invasive tissue sampling. (C) 2017 SETAC
机译：汞是全球关注的污染物。水獭（Lontra canadensis）和水貂（Neovison vison）等前哨物种通常用于监测淡水生态系统中的环境浓度。组织总Hg（THg）浓度经常用作暴露的生物标志物。但是，没有关于不同组织中汞组织浓度的综合模型，因此研究间的比较具有挑战性。我们的目标是使用文献中报道的平均浓度和标准误差来建立与毛皮，大脑，肝脏，肾脏和肌肉THg浓度相关的转换因子。我们使用了来自北美和欧洲16个研究和96个采样点的6000多个样本的数据。对水獭和水貂模型进行了十六次回归，在95％的置信区间上具有统计学意义，并产生了较高的解释方差。使用单独测量的THg组织浓度的外部数据集验证了模型。经过验证的转化率可用于评估当前的20 g g / g和30 g g / g的毛皮汞筛查指南。在这两种毛皮浓度下，大脑浓度都与改变大脑神经化学有关。我们建议采用更为保守的皮毛汞筛查准则，即15微克/克，以保护敏感的皮鞋制造商。转换因子可用于通过皮毛测量预测内部器官THg浓度，从而无需进行侵入性组织采样。 （C）2017年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第9期|1-16|共16页
  • 作者

    Eccles Kristin M.; Thomas Philippe J.; Chan Hing Man;

  • 作者单位

    Univ Ottawa, Dept Biol, Ottawa, ON, Canada;

    Univ Ottawa, Dept Biol, Ottawa, ON, Canada|Carleton Univ, Natl Wildlife Res Ctr, Sci & Technol Branch, Environm & Climate Change Canada, Ottawa, ON, Canada;

    Univ Ottawa, Dept Biol, Ottawa, ON, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mink; River otter; Mercury; Biomarker; Conversion factor;

    机译：水貂;水獭;水星;生物标志物;转化因子;

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