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首页> 外文期刊>Environmental toxicology and chemistry >BIOCHEMICAL ALTERATIONS IN DUCKWEED AND ALGAE INDUCED BY CARRIER SOLVENTS: SELECTION OF AN APPROPRIATE SOLVENT IN TOXICITY TESTING
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BIOCHEMICAL ALTERATIONS IN DUCKWEED AND ALGAE INDUCED BY CARRIER SOLVENTS: SELECTION OF AN APPROPRIATE SOLVENT IN TOXICITY TESTING

机译：载体溶剂诱导的浮萍和藻类的生物化学变化：毒性测试中适当溶剂的选择

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摘要

Carrier solvents are often used in aquatic toxicity testing for test chemicals with hydrophobic properties. However, the knowledge of solvent effects on test organisms remains limited. The present study aimed to determine the biochemical effects of the 4 common solvents methanol, ethanol, acetone, and dimethyl sulfoxide (DMSO) on 2 test species, Lemna minor and Raphidocelis subcapitata, by applying Fourier transform infrared spectroscopy (FTIR) coupled with multivariate analysis to select appropriate solvents for toxicity testing. The results showed biochemical variations associated with solvent treatments at different doses on test species. From the infrared spectra obtained, the structures of lipid membrane and protein phosphorylation in the test species were found to be sensitive to the solvents. Methanol and ethanol mainly affected the protein secondary structure, whereas acetone and DMSO primarily induced alterations in carbohydrates and proteins in the test species. The FTIR results demonstrated that methanol and ethanol showed higher biochemical alterations in the test species than acetone and DMSO, especially at the high doses (0.1 and 1% v/v). Based on the growth inhibition displayed and FTIR spectroscopy, acetone, and DMSO can be used as carrier solvents in toxicity testing when their (C) 2017 SETAC
机译：载体溶剂通常用于水生毒性测试中，以测试具有疏水性的化学药品。但是，溶剂对受试生物影响的知识仍然有限。本研究旨在通过应用傅立叶变换红外光谱（FTIR）结合多变量分析来确定4种常见溶剂甲醇，乙醇，丙酮和二甲基亚砜（DMSO）对2个测试物种Lemna minor和Raphidocelis subcapitata的生化作用选择适当的溶剂进行毒性测试。结果显示在测试物种上不同剂量的溶剂处理相关的生化变化。从获得的红外光谱中，发现测试物种中的脂质膜和蛋白质磷酸化的结构对溶剂敏感。甲醇和乙醇主要影响蛋白质的二级结构，而丙酮和DMSO主要引起测试物种中碳水化合物和蛋白质的改变。 FTIR结果表明，甲醇和乙醇在测试物种中比丙酮和DMSO表现出更高的生化变化，尤其是在高剂量（0.1和1％v / v）下。基于显示的生长抑制作用和FTIR光谱，当（C）2017 SETAC时，丙酮和DMSO可用作毒性测试中的载体溶剂

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第10期|2631-2639|共9页
  • 作者

    Hu Li-Xin; Tian Fei; Martin Francis L.; Ying Guang-Guo;

  • 作者单位

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|Univ Chinese Acad Sci, Beijing, Peoples R China;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China;

    Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston, Lancs, England;

    Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou, Guangdong, Peoples R China|South China Normal Univ, Key Lab Environm Theoret Chem, MOE, Environm Res Inst, Guangzhou, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Toxicity test; Carrier solvent; Fourier transform infrared spectroscopy; Biochemical fingerprint;

    机译：毒性试验载体溶剂傅里叶变换红外光谱生化指纹图谱;

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