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Mercury speciation and subcellular distribution in experimentally dosed and wild birds

机译：实验剂量和野生鸟类中的汞形态和亚细胞分布

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摘要

Many bird species are exposed to methylmercury (MeHg) at levels shown to cause sublethal effects. Although MeHg sensitivity and assimilation can vary among species and developmental stages, the underlying reasons (such as MeHg toxicokinetics) are poorly understood. We investigated Hg distribution at the tissue and cellular levels in birds by examining Hg speciation in blood, brain, and liver and Hg subcellular distribution in liver. We used MeHg egg injection of white leghorn chicken (Gallus gallus domesticus), sampled at 3 early developmental stages, and embryonic ring-billed gulls (Larus delawarensis) exposed to maternally deposited MeHg. The percentage of MeHg (relative to total Hg [THg]) in blood, brain, and liver ranged from 94 to 121%, indicating little MeHg demethylation. A liver subcellular partitioning procedure was used to determine how THg was distributed between potentially sensitive and detoxified compartments. The distributions of THg among subcellular fractions were similar among chicken time points, and between embryonic chicken and ring-billed gulls. A greater proportion of THg was associated with metal-sensitive fractions than detoxified fractions. Within the sensitive compartment, THg was found predominately in heat-denatured proteins (approximate to 42-46%), followed by mitochondria (approximate to 15-18%). A low rate of MeHg demethylation and high proportion of THg in metal-sensitive subcellular fractions further indicates that embryonic and hatchling time points are Hg-sensitive developmental stages, although further work is needed across a range of additional species and life stages. Environ Toxicol Chem 2017;36:3289-3298. (c) 2017 SETAC
机译：许多鸟类都暴露于甲基汞（MeHg）中，其含量表明会引起亚致死作用。尽管MeHg的敏感性和同化作用因物种和发育阶段而异，但其根本原因（例如MeHg毒代动力学）知之甚少。我们通过检查血液，大脑和肝脏中的汞形态以及肝脏中的汞亚细胞分布，研究了鸟类在组织和细胞水平上的汞分布。我们使用MeHg卵注射白色来亨鸡（Gallus gallus domesticus）的鸡蛋，在3个早期发育阶段进行采样，并使用暴露于母体沉积的MeHg的胚胎环嘴鸥（Larus delawarensis）。血液，脑和肝脏中的MeHg百分比（相对于总Hg [THg]）介于94％至121％之间，表明MeHg几乎没有甲基化。肝亚细胞分配程序用于确定THg在潜在敏感区和解毒区室之间的分布方式。在鸡的时间点之间，以及在胚胎鸡和环嘴鸥之间，亚细胞组分中THg的分布相似。与金属敏感级分相关的THg比例要高于排毒级分。在敏感区室中，THg主要存在于热变性蛋白中（约42-46％），其次是线粒体（约15-18％）。在金属敏感的亚细胞级分中，MeHg脱甲基化率低和THg比例高，这进一步表明，胚胎和孵化时间点是Hg敏感的发育阶段，尽管在其他物种和生命阶段还需要进一步的工作。 Environ Toxicol Chem 2017; 36：3289-3298。 （c）2017年SETAC

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  • 来源
    《Environmental toxicology and chemistry》 |2017年第12期|3289-3298|共10页
  • 作者

    Perkins Marie; Barst Benjamin D.; Hadrava Justine; Basu Niladri;

  • 作者单位

    McGill Univ, Dept Nat Resource Sci, Montreal, PQ, Canada;

    McGill Univ, Dept Nat Resource Sci, Montreal, PQ, Canada;

    McGill Univ, Dept Nat Resource Sci, Montreal, PQ, Canada;

    McGill Univ, Dept Nat Resource Sci, Montreal, PQ, Canada|McGill Univ, Sch Dietet & Human Nutr, Montreal, PQ, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Mercury; Subcellular fractions; Toxicokinetics; Birds; Liver;

    机译：汞;亚细胞级分;毒代动力学;鸟类;肝脏;

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