MOSAIC_SSD: A NEW WEB TOOL FOR SPECIES SENSITIVITY DISTRIBUTION TO INCLUDE CENSORED DATA BY MAXIMUM LIKELIHOOD

Guillaume Kon Kam King; Philippe Veber; Sandrine Charles; Marie Laure Delignette-Muller

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MOSAIC_SSD: A NEW WEB TOOL FOR SPECIES SENSITIVITY DISTRIBUTION TO INCLUDE CENSORED DATA BY MAXIMUM LIKELIHOOD

机译：MOSAIC_SSD：一种用于物种敏感度分布的新Web工具，以最大似然法包含经过审查的数据

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Censored data are seldom taken into account in species sensitivity distribution (SSD) analysis. However, they are found in virtually every dataset and sometimes represent the better part of the data. Stringent recommendations on data quality often entail discarding a lot of these meaningful data, resulting in datasets of reduced size which lack representativeness of any realistic community. However, it is reasonably simple to include censored data in SSD by using an extension of the standard maximum likelihood method. The authors detail this approach based on the use of the R-package fitdistrplus, dedicated to the fit of parametric probability distributions. The authors present the new Web tool MOSAIC_SSD, that can fit an SSD on datasets containing any type of data, censored or not. The MOSAIC_SSD Web tool predicts any hazardous concentration and provides bootstrap confidence intervals on the predictions. Finally, the authors illustrate the added value of including censored data in SSD, taking examples from published data.

机译：在物种敏感度分布（SSD）分析中很少考虑到经过审查的数据。但是，它们几乎在每个数据集中都可以找到，有时代表数据的更好部分。关于数据质量的严格建议通常需要丢弃很多这些有意义的数据，从而导致数据集的大小减小，从而缺乏任何现实社区的代表性。但是，通过使用标准最大似然方法的扩展，将经过审查的数据包含在SSD中相当简单。作者基于专用于参数概率分布拟合的R包fitdistrplus的使用，详细介绍了这种方法。作者介绍了新的Web工具MOSAIC_SSD，它可以在包含任何类型的数据的数据库中安装SSD，无论数据类型是否经过审查。 MOSAIC_SSD Web工具可预测任何危险浓度，并根据预测提供引导置信区间。最后，作者以发布数据中的示例为例，说明了将审查数据包含在SSD中的附加值。

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来源
《Environmental toxicology and chemistry》 |2014年第9期|2133-2139|共7页
作者
Guillaume Kon Kam King; Philippe Veber; Sandrine Charles; Marie Laure Delignette-Muller;
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作者单位

UMR CNRS 5558-Laboratoire de Biometrie et Biologie Evolutive, Unviersite Claude Bernard, Lyon, Villeurbanne, France;

UMR CNRS 5558-Laboratoire de Biometrie et Biologie Evolutive, Unviersite Claude Bernard, Lyon, Villeurbanne, France;

UMR CNRS 5558-Laboratoire de Biometrie et Biologie Evolutive, Unviersite Claude Bernard, Lyon, Villeurbanne, France,Institut Universitaire de France, Paris, France;

UMR CNRS 5558-Laboratoire de Biometrie et Biologie Evolutive, Unviersite Claude Bernard, Lyon, Villeurbanne, France,VetAgro Sup, Campus Veterinaire de Lyon, Marcy l'etoile, France;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
Bootstrap; Confidence interval; Web interface; Fitdistrplus; Hazardous concentration;

机译：引导程序置信区间网络界面;Fitdistrplus;危险浓度;

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MOSAIC_SSD: A NEW WEB TOOL FOR SPECIES SENSITIVITY DISTRIBUTION TO INCLUDE CENSORED DATA BY MAXIMUM LIKELIHOOD

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