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首页> 外文期刊>Environmental toxicology and chemistry >SUBLETHAL EFFECTS OF THE BETA-BLOCKER SOTALOL AT ENVIRONMENTALLY RELEVANT CONCENTRATIONS ON THE NEW ZEALAND MUDSNAIL POTAMOPYRGUS ANTIPODARUM
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SUBLETHAL EFFECTS OF THE BETA-BLOCKER SOTALOL AT ENVIRONMENTALLY RELEVANT CONCENTRATIONS ON THE NEW ZEALAND MUDSNAIL POTAMOPYRGUS ANTIPODARUM

机译：环境相关浓度的β-阻滞剂索他洛尔对纽西兰鼠疫对虾抗菌药的影响

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摘要

Monitoring sublethal effects of Pharmaceuticals on nontarget species in aquatic environments has become an important topic in ecotoxicology, yet few studies have been conducted concerning the effects of beta-blockers on aquatic organisms. The present study investigated the effects of the beta-blocker sotalol (SOT) at 3 environmentally relevant concentrations on life-history traits of the New Zealand mudsnail Potamopyrgus antipodarum. Based on the pharmacodynamic properties of SOT, the authors hypothesized reduced numbers of embryos in the brood pouches, decelerated growth of adult snails, and smaller size of neonates, but no effect on mortality rates of adults. Contrary to the hypothesis, the total number of embryos was significantly higher after 56 d of exposure at nominal concentrations of 0.05 μg/L and 1.0 μg/L by 107% and 73%, respectively. No differences in embryo numbers were observed at earlier time-points. Therefore, the mode of action seems to be an extension of the reproductive period rather than an increase of the embryo production. Furthermore, our results indicate a hormetic dose-response relationship, because no effects were observed at the highest test-concentration (6.5 μg/L). Mortality, growth of adult snails, and neonate sizes were not affected by the beta-blocker. Given the strong influence on reproduction, the effects of sublethal concentrations of SOT and other beta-blockers deserve better consideration in ecotoxicological risk assessment.
机译：监测药物对水生环境中非靶标物种的亚致死作用已成为生态毒理学的重要课题，然而，有关β受体阻滞剂对水生生物的影响的研究很少。本研究调查了3种环境相关浓度的β受体阻滞剂索他洛尔（SOT）对新西兰泥螺Potamopyrgus antipodarum的生活史特征的影响。基于SOT的药代动力学特性，作者假设育雏袋中的胚胎数量减少，成年蜗牛的生长速度降低以及新生儿的体型较小，但对成年死亡率没有影响。与该假设相反，暴露56 d后，标称浓度为0.05μg/ L和1.0μg/ L时，胚胎总数分别明显增加了107％和73％。在较早的时间点没有观察到胚胎数量的差异。因此，作用方式似乎是生殖期的延长，而不是胚胎产量的增加。此外，我们的研究结果表明了激素剂量-反应关系，因为在最高测试浓度（6.5μg/ L）下未观察到任何影响。 β受体阻滞剂不影响死亡率，成年蜗牛的生长和新生儿大小。考虑到对生殖的强烈影响，亚致死浓度的SOT和其他β受体阻滞剂的影响在生态毒理学风险评估中值得更好地考虑。

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  • 来源
    《Environmental toxicology and chemistry》 |2014年第11期|2510-2515|共6页
  • 作者

    Mona Feiner; Christian Laforsch; Thomas Letzel; Juergen Geist;

  • 作者单位

    Aquatic Systems Biology Unit, Department of Ecology and Ecosystem Management, Technische Universitaet Muenchen, Freising, Germany;

    Department of Animal Ecology Ⅰ, University of Bayreuth, Bayreuth, Germany;

    Urban Water Systems Engineering, Technische Universitaet Muenchen, Garching, Germany;

    Aquatic Systems Biology Unit, Department of Ecology and Ecosystem Management, Technische Universitaet Muenchen, Freising, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Pharmaceutical; Invertebrate; Xenobiotic; Reproduction; Mollusk;

    机译：制药;无脊椎动物异种生物;再生产;软体动物;

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