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首页> 外文期刊>Environmental toxicology and chemistry >EFFECT OF REDUCED FOOD INTAKE ON TOXICOKINETICS OF HALOGENATED ORGANIC CONTAMINANTS IN HERRING GULL (LARUS ARGENTATUS) CHICKS
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EFFECT OF REDUCED FOOD INTAKE ON TOXICOKINETICS OF HALOGENATED ORGANIC CONTAMINANTS IN HERRING GULL (LARUS ARGENTATUS) CHICKS

机译：减少食物摄入量对海鸥雏鸡中卤化有机污染物的毒性动力学的影响

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摘要

The aim of the present study was to investigate how contaminant exposure and reduced food intake affect tissue distribution and biotransformation of halogenated organic contaminants (HOCs) in Arctic seabirds using herring gull (Larus argentatus) as a model species. Herring gull chicks were exposed for 44 d to cod liver oil containing a typical mixture of contaminants. Following exposure, food intake was reduced for a one-week period in a subgroup of the chicks. Polyclorinated biphenyls, organochlorine pesticides, and brominated flame retardants, as well as a wide range of hydroxy, methyl sulfone, and methoxy compounds were measured in liver, brain, and plasma samples. Additionally, phase I biotransformation enzyme activities and phase I and II messenger ribonucleic acid (mRNA) expression were investigated in the liver, brain, or both. Both contaminant exposure and reduced food intake had an increasing effect on the concentrations of HOCs and their metabolites. The HOC exposure and reduced food intake also led to increased 7-ethoxyresorufin-O-deethylation (EROD) activity, whereas mRNA expression of the biotransformation enzymes increased only following the reduced food intake. Tissue distribution of HOCs and their metabolites was not affected by either contaminant exposure or reduced food intake. In conclusion, the results indicate that biotransformation capacity and formation of HOC metabolites increase during reduced food intake. This finding supports the hypothesis that reduced food intake increases the susceptibility of Arctic animals to the effects of lipophilic HOCs.
机译：本研究的目的是使用鲱鸥（Argustus）作为模型物种，研究污染物暴露和食物摄入减少如何影响北极海鸟的组织分布和卤代有机污染物（HOC）的生物转化。将鲱鸥雏鸡暴露于含有典型污染物混合物的鱼肝油中44天。接触后，小鸡亚组的食物摄入量减少了一周。在肝脏，大脑和血浆样品中测量了多氯联苯，有机氯农药和溴化阻燃剂，以及各种羟基，甲基砜和甲氧基化合物。此外，还研究了肝脏，大脑或两者中的I期生物转化酶活性以及I期和II期信使核糖核酸（mRNA）表达。污染物暴露和食物摄入减少对HOC及其代谢物的浓度都有增加的影响。 HOC暴露和食物摄入减少也导致7-乙氧基异鲁布丁-O-脱乙基（EROD）活性增加，而生物转化酶的mRNA表达仅在食物摄入减少后才增加。 HOC及其代谢产物的组织分布不受污染物暴露或食物摄入减少的影响。总之，结果表明在减少食物摄入的过程中，生物转化能力和HOC代谢物的形成增加。这一发现支持以下假设：减少食物摄入会增加北极动物对亲脂性HOC的敏感性。

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