Letter to the Editor

RalfB. Schiifer; Mirco Bundschuh; Landau Germany; Andreas Focks; Peter C.

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Letter to the Editor

机译：给编辑的一封信

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Ecotoxicology is a relatively new scientific discipline that aims at examining the fate and effects of chemicals in the environment. It is an applied science, where most studies are conducted under standardized laboratory conditions. In laboratory studies, individuals, or to a smaller extent, populations, of a given taxon (mainly a few standard test organisms) are exposed to a single chemical or a mixture of chemicals for a predefined time period [1,2]. The ecotoxicological risk assessment is primarily based on experimental data. Given the large number of compounds in commerce, it seems impossible to generate ecotoxicity data for all combinations of compounds and relevant biotic endpoints (spanning from the molecular to the ecosystem level) [3]. Therefore, it is crucial to develop modeling frameworks that allow for the prediction of effects if no or limited experimental data is available [4]. Such modeling frameworks include quantitative-structure activity relationships (QSARs), toxicokinetic and toxicodynamic models, and matrix population and individual-based eco(toxico)logical models [5].

机译：生态毒理学是一门相对较新的科学学科，旨在研究化学物质在环境中的命运和影响。这是一门应用科学，其中大多数研究都是在标准化实验室条件下进行的。在实验室研究中，给定分类单元（主要是几种标准测试生物）的个体（或程度较小的种群）在预定的时间段内暴露于单一化学物质或化学物质混合物[1,2]。生态毒理风险评估主要基于实验数据。鉴于商业中有大量化合物，似乎不可能为化合物和相关生物终点（从分子水平到生态系统水平）的所有组合生成生态毒性数据[3]。因此，开发建模框架至关重要，如果没有可用的或有限的实验数据，该模型框架就可以预测效果[4]。这样的建模框架包括定量结构活性关系（QSAR），毒物动力学和毒物动力学模型，以及基质种群和基于个体的生态（毒理）逻辑模型[5]。

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来源
《Environmental toxicology and chemistry》 |2013年第4期|734-735|共2页
作者
RalfB. Schiifer; Mirco Bundschuh; Landau Germany; Andreas Focks; Peter C.;
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作者单位

University Koblenz-Landau Landau, Germany;

University Koblenz-Landau;

Swedish University of Agricultural Sciences Uppsala, Sweden;

Wageningen University Aquatic Ecology and Water Quality Management Group Wageningen, The Netherlands;

Helmholtz Centre for Environmental Research-UFZ Leipzig, Germany;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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专利

1. Letter to the Editor Comments on the “Letter to the editor” by M.-L. You and C.-M. Shu (Journal of Thermal Analysis and Calorimetry, 2010;100:367–369) as response to the “Letter to the editor” by M. Malow and K.-D. Wehrstedt (Journal of Thermal Analysis and Calorimetry, 2009;98:885–886) [J] . K. D. Wehrstedt, M. Malow Journal of Thermal Analysis and Calorimetry . 2011,第1期

机译：致编辑的信M.-L对“致编辑的信”的评论。您和C.-M. Shu（《热分析与色度学杂志》，2010年； 100：367-369）是对M. Malow和K.-D的“致编辑的信”的回应。 Wehrstedt（热分析与量热杂志，2009； 98：885-886）
2. Letter to the Editor Letters to the Editor should be submitted online to www.editorialmanager.com/amsurg [J] . Alireza Hamidian Jahromi, Richard Wigle, Asser M. Youssef The American surgeon. . 2011,第12期

机译：致编辑的信致编辑的信应在线提交至www.editorialmanager.com/amsurg
3. Editor's note concerning letter to the editor by DE Roth and response to letter to the editor by V Bhatia et al. [J] . Shetty PS European journal of clinical nutrition . 2010,第8期

机译：关于DE Roth给编辑的信以及V Bhatia等人写给编辑的信的编者注。
4. LETTER FROM THE ASSOCIATE EDITORS [C] . Rainer Gemulla International conference on very large data bases . 2015

机译：副编辑的信
5. How S. C. Daily Newspapers Framed the Removal of the Confederate Flag from the State House Grounds in 2015 Through Letters to the Editor and Editorials [D] . Anderson, Thomas Craig. 2018

机译：S. C.日报如何通过致编辑和社论的信来构筑2015年从州议会大厦拆除同盟国国旗的框架
6. Letter to the Editors: Concerning Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state by Takashi et al. and Letter to the Editors by Ortolano et al. [O] . Anne Schänzer, Kerstin Giese, Lara Viergutz, 2017

机译：致编辑的信：Takashi等人有关α-葡萄糖苷酶替代疗法在有症状或症状前状态下接受治疗的两个婴儿发作的庞贝病兄弟姐妹中的不同临床结果。和Ortolano等人写给编辑的信。
7. Letter to the Editors: Concerning “Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state” by Takashi et al. and Letter to the Editors by Ortolano et al. [O] . Anne Schänzer, Kerstin Giese, Lara Viergutz, 2017

机译：致编辑的信：关于“在症状性或症状前状态下治疗的婴儿期发作的pompe病的两个兄弟姐妹中α-葡萄糖苷酶替代治疗的不同临床结果”，Takashi等人。和Ortolano等人给编辑的信。

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