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首页> 外文期刊>Environmental toxicology and chemistry >DIETARY EXPOSURE OF MINK (MUSTELA VISON) TO FISH FROM THE UPPER HUDSON RIVER, NEW YORK, USA: EFFECTS ON ORGAN MASS AND PATHOLOGY
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DIETARY EXPOSURE OF MINK (MUSTELA VISON) TO FISH FROM THE UPPER HUDSON RIVER, NEW YORK, USA: EFFECTS ON ORGAN MASS AND PATHOLOGY

机译：饮食（美国纽约州上哈德逊河）的貂对鱼的饮食暴露：对器官质量和病理的影响

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摘要

Abstract-The authors evaluated effects of feeding ranch mink (Mustela vison) diets containing polychlorinated biphenyl (PCB)-contaminated fish from the upper Hudson River (New York, USA) on adult and offspring organ mass and pathology. Diets contained 2.5 to 20% Hudson River fish, providing 0.72 to 6.1 μg XPCBs/g feed (4.8-38 pg toxic equivalents [TEQ_(WHO) 20os]/g feed). Absolute thyroid and adrenal gland masses were increased in adult females and 31-week-old juveniles, respectively, and absolute liver and heart masses were decreased in six-week-old kits exposed to dietary PCBs. Dietary concentrations of 0.72 μg ∑PCBs/g feed (4.8 pg TEQ_(WHO) 2005/g feed) and greater induced mandibular and maxillary squamous epithelial proliferation in adult animals. The dietary concentration of XPCBs predicted to result in 20% incidence of the jaw lesion (EC20) was 2.3 μg XPCBs/g feed (15 pg TEQ_(WHO) 2005/g feed), and the hepatic concentration was 2.8 μg XPCBs/g liver (89 pg TEQ_(WHO) 2005/g liver). The EC20 values were greater than the dietary and hepatic concentrations predicted to result in a 20% increase in kit mortality (LC20) at six weeks of age (0.34 μg ∑PCBs/g feed or 2.6 pg TEQ_(WHO) 2005/g feed and 0.80 μg 2PCBs/g liver or 13 pg TEQ_(WHO) 2005/g liver). However, the EC20 values reflect exposure of adults to PCBs for approximately six months, and the LC20 values reflect exposure of offspring from conception onward.
机译：摘要-作者评估了饲喂含有来自哈德逊河上游（美国纽约）的被多氯联苯（PCB）污染的鱼的水貂（Mustela vison）日粮对成年和后代器官质量和病理学的影响。日粮中含有2.5％至20％的哈德逊河鱼类，提供的0.72至6.1μgXPCBs / g饲料（4.8-38 pg毒性当量[TEQ_（WHO）20os] / g饲料）。成年女性和31周龄青少年的绝对甲状腺和肾上腺肿块分别增加，而暴露于膳食多氯联苯的六周龄药盒中的绝对肝脏和心脏绝对质量降低。日粮浓度为0.72μg∑PCBs / g饲料（4.8 pg TEQ_（WHO）2005 / g饲料），并且成年动物的下颌和上颌鳞状上皮增生程度更高。预计导致20％的颚部病变（EC20）发生的日粮XPCB浓度为2.3μgXPCBs / g饲料（15 pg TEQ_（WHO）2005 / g饲料），肝脏浓度为2.8μgXPCBs / g肝脏（89 pg TEQ_（WHO）2005 / g肝脏）。 EC20值大于预期的饮食和肝脏中的浓度，导致六周龄时试剂盒死亡率（LC20）增加20％（0.34μg∑PCBs / g饲料或2.6 pg TEQ_（WHO）2005 / g饲料和0.80μg2PCBs / g肝或13 pg TEQ_（WHO）2005 / g肝）。但是，EC20值反映了成年人在PCB中接触了大约六个月，而LC20值反映了从怀孕开始的后代接触。

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  • 来源
    《Environmental toxicology and chemistry》 |2013年第4期|794-801|共8页
  • 作者

    Steven J. Bursian; John Kern; .Richard E. Remington; Jane E. LiNK; Scott D. Fitzgerald;

  • 作者单位

    Department of Animal Science, Michigan State University, East Lansing, Michigan, USA ,Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA;

    KERN Statistical Services, Sauk Rapids, Minnesota, USA;

    KERN Statistical Services, Sauk Rapids, Minnesota, USA;

    Department of Animal Science, Michigan State University, East Lansing, Michigan, USA;

    Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA ,Diagnostic Center for Population and Animal Health, Michigan State University, Lansing, Michigan, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hudson river; mink; polychlorinated biphenyl; organ weight; pathology;

    机译：哈德逊河貂;多氯联苯;器官重量;病理;

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