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首页> 外文期刊>Environmental toxicology and chemistry >A NEW MEDIUM FOR CAENORHABDITIS ELEGANS TOXICOLOGY AND NANOTOXICOLOGY STUDIES DESIGNED TO BETTER REFLECT NATURAL SOIL SOLUTION CONDITIONS
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A NEW MEDIUM FOR CAENORHABDITIS ELEGANS TOXICOLOGY AND NANOTOXICOLOGY STUDIES DESIGNED TO BETTER REFLECT NATURAL SOIL SOLUTION CONDITIONS

机译：一种旨在更好地反映天然土壤溶液状况的新的食蟹猴线毒理学和纳米毒理学研究介质

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摘要

A new toxicity test medium for Caenorhabditis elegans is presented. The test solution is designed to provide a better representation of natural soil pore water conditions than currently available test media. The medium has a composition that can readily be modified to allow for studies of the influences of a range of environmentally relevant parameters on nematode biology and toxicology. Tests conducted in the new medium confirmed that nematodes' reproduction was possible at a range of solution pH levels, offering the potential to conduct toxicity studies under a variety of conditions. A test to establish silver nanoparticle and dissolved silver nitrate toxicity, a study type not feasible in M9 or agar media due to precipitation and nanoparticle agglomeration, indicated lower silver nanoparticle (median effective concentration [EC50] of 6.5 mg Ag/L) than silver nitrate (EC50 0.28 mg Ag/L) toxicity. Characterization identified stable nanoparticle behavior in the new test medium.
机译：提出了一种新的秀丽隐杆线虫毒性试验介质。与当前可用的测试介质相比，该测试解决方案旨在更好地表示天然土壤孔隙水状况。培养基的成分易于修饰，可用于研究一系列环境相关参数对线虫生物学和毒理学的影响。在新培养基中进行的测试证实，线虫在一定范围的溶液pH值水平下都可以繁殖，这提供了在各种条件下进行毒性研究的潜力。一项确定银纳米颗粒和溶解的硝酸银毒性的试验（由于沉淀和纳米颗粒团聚而在M9或琼脂培养基中不可行的研究类型）表明，银纳米颗粒（中位有效浓度[EC50]为6.5 mg Ag / L）低于硝酸银（EC50 0.28 mg Ag / L）毒性。表征鉴定了在新的测试介质中稳定的纳米颗粒行为。

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  • 来源
    《Environmental toxicology and chemistry》 |2013年第8期|1711-1717|共7页
  • 作者

    William Tyne; Stephen Lofts; David J. Spurgeon; Kerstin Jurkschat; Claus Svendsen;

  • 作者单位

    Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom;

    Centre for Ecology and Hydrology, Bailrigg, Lancaster, United Kingdom;

    Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom;

    Department of Materials, Oxford University, Begbroke Science Park, Yamton, Oxford, United Kingdom;

    Centre for Ecology and Hydrology, Crowmarsh Gifford, Wallingford, Oxfordshire, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Nanoparticle; Silver; Toxicity test; Ionic strength; Fulvic acid; pH;

    机译：纳米粒子银;毒性测试;离子强度;黄腐酸;pH值;

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