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首页> 外文期刊>Environmental toxicology and chemistry >SEASONAL EMACIATION CAUSES TISSUE REDISTRIBUTION AND AN INCREASED POTENTIAL FOR TOXICITY OF LIPOPHILIC POLLUTANTS IN FARMED ARCTIC FOX (VULPES LAGOPUS)
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SEASONAL EMACIATION CAUSES TISSUE REDISTRIBUTION AND AN INCREASED POTENTIAL FOR TOXICITY OF LIPOPHILIC POLLUTANTS IN FARMED ARCTIC FOX (VULPES LAGOPUS)

机译：季节化成因导致组织重新分布，并增加了家养北极狐（Vulpes Lagopus）中脂类污染物的毒性潜能

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摘要

Many Arctic animals carry high body burdens of organochlorine contaminants (OCs) as a result of long-range transport of persistent pollutants. It has been shown that seasonal mobilization of body fat in these species results in increased blood concentration of OCs. The authors investigated OC assimilation, tissue distribution, and biotransformation in fanned Arctic fox (Vulpes lagopus) continuously fed a diet containing contaminated minke whale blubber or lard (control) from 8 wk of age in August 2003, until sampling when they were at their fattest (in November 2004) and leanest (in June 2005). Markedly higher tissue (liver, adrenals, brain, and blood) OC levels were found in June than in November despite low exposure to OCs during emaciation, suggesting that OCs had been redistributed from adipose tissues to vital organs. There were no differences in the activities of hepatic biotransforming enzymes between exposed fat and control fat foxes, except for 16α-hydroxylation, which was higher in exposed fat foxes. In emaciated foxes, ethoxyresorufin activity was higher in exposed than in control foxes, indicating an enhanced potential for toxicity of OCs with emaciation. Lower activities of 6β- and 2β-hydroxylation were found in lean than in fat foxes, irrespective of OC treatment. The results show that emaciation increase the toxic potential of accumulated OCs and emphasize that body adiposity must be considered when time-trend analyses, risk assessments, and effect studies are designed.
机译：由于长期传播持久性污染物，许多北极动物携带大量有机氯污染物（OCs）。已经表明，这些物种中身体脂肪的季节性动员会导致OCs血液浓度增加。作者调查了扇形北极狐（Vulpes lagopus）中的OC同化，组织分布和生物转化，该实验自2003年8月起从8周龄开始，连续饲喂含有受污染的小须鲸脂或猪油（对照组）的饮食，直到取样达到最胖（2004年11月）和最瘦（2005年6月）。尽管在消瘦过程中接触低水平的OC，6月发现的组织（肝脏，肾上腺，大脑和血液）的OC水平明显高于11月，这表明OC已从脂肪组织重新分布到重要器官。暴露的脂肪狐狸和对照脂肪狐狸之间的肝脏生物转化酶活性没有差异，除了16α-羟化作用外，脂肪暴露的狐狸更高。在瘦弱的狐狸中，暴露后的乙氧基间苯二酚活性高于对照狐狸，这表明OCs消瘦时具有更大的毒性潜力。与脂肪狐狸相比，瘦肉中的6β和2β羟基化活性较低，与OC处理无关。结果表明，消瘦可增加积累的OC的潜在毒性，并强调在设计时间趋势分析，风险评估和效果研究时必须考虑身体肥胖。

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  • 来源
    《Environmental toxicology and chemistry》 |2013年第8期|1784-1792|共9页
  • 作者

    Lisa B. Helgason; Hans Wolkers; Eva Fuglei; Oystein Ahlstrom; Derek Muir; Even H. Jorgensen;

  • 作者单位

    Faculty of Biosciences, Fisheries and Economics, University of Tromso, Tromso, Norway,Norwegian Polar Institute, Fram Centre, Tromso, Norway;

    Norwegian Polar Institute, Fram Centre, Tromso, Norway,Wageningen University and Research Centre, AK Wageningen, The Netherlands;

    Norwegian Polar Institute, Fram Centre, Tromso, Norway;

    Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, As, Norway;

    Aquatic Ecosystem Protection Research Division, Environment Canada, Burlington, Ontario, Canada;

    Faculty of Biosciences, Fisheries and Economics, University of Tromso, Tromso, Norway,Norwegian Institute for Nature Research, Fram Centre, Tromso, Norway;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Farmed Arctic fox; Persistent organic pollutants; Organochlorines; Emaciation; Biotransformation; CYP; enzymes;

    机译：养殖的北极狐;持久性有机污染物;有机氯;消瘦;生物转化;CYP;酵素;

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