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首页> 外文期刊>Environmental toxicology and chemistry >INTERSPECIES COMPARISONS ON THE UPTAKE AND TOXICITY OF SILVER AND CERIUM DIOXIDE NANOPARTICLES
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INTERSPECIES COMPARISONS ON THE UPTAKE AND TOXICITY OF SILVER AND CERIUM DIOXIDE NANOPARTICLES

机译：银和二氧化铈纳米粒子吸收和毒性的种间比较

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摘要

An increasing number and quantity of manufactured nanoparticles are entering the environment as the diversity of their applications increases, and this will lead to the exposure of both humans and wildlife. However, little is known regarding their potential health effects. We compared the potential biological effects of silver (Ag; nominally 35 and 600-1,600 nm) and cerium dioxide (CeO_2; nominally <25 nm and 1-5 μm) particles in a range of cell (human hepatocyte and intestinal and fish hepatocyte) and animal (Daphnia magna, Cyprinus carpio) models to assess possible commonalities in toxicity across taxa. A variety of analytical techniques were employed to characterize the particles and investigate their biological uptake. Silver particles were more toxic than CeO_2 in all test systems, and an equivalent mass dose of Ag nanoparticles was more toxic than larger micro-sized material. Cellular uptake of all materials tested was shown in C3A hepatocytes and Caco-2 intestinal cells, and for Ag, into the intestine, liver, gallbladder, and gills of carp exposed via the water. The commonalities in toxicity of these particle types across diverse biological systems suggest that cross-species extrapolations may be possible for metal nanoparticle test development in the future. Our findings also suggest transport of particles through the gastrointestinal barrier, which is likely to be an important uptake route when assessing particle risk.
机译：随着用途的多样性增加，越来越多的人造纳米颗粒进入环境，这将导致人类和野生生物的接触。然而，对其潜在的健康影响知之甚少。我们比较了银（Ag；名义上35和600-1,600 nm）和二氧化铈（CeO_2；名义上<25 nm和1-5μm）颗粒在一系列细胞（人肝细胞，肠和鱼肝细胞）中的潜在生物效应。和动物模型（Daphnia magna，Cyprinus carpio）模型来评估整个分类单元中毒性的可能共性。采用了多种分析技术来表征颗粒并研究其生物学吸收。在所有测试系统中，银粒子比CeO_2更具毒性，等效质量剂量的银纳米粒子比较大的微米级材料更具毒性。在C3A肝细胞和Caco-2肠细胞中以及在Ag中，通过水暴露的鲤鱼的肠，肝，胆囊和g均显示出细胞对所有测试物质的细胞摄取。这些粒子类型在各种生物系统中的毒性共有性表明，跨物种外推法可能会在将来用于金属纳米粒子测试的开发。我们的发现还表明颗粒通过胃肠道转运，这在评估颗粒风险时可能是重要的摄取途径。

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