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首页> 外文期刊>Environmental toxicology and chemistry >HIGH POLYBROMINATED DIPHENYL ETHER LEVELS IN CALIFORNIA HOUSE CATS:HOUSE DUST A PRIMARY SOURCE?
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HIGH POLYBROMINATED DIPHENYL ETHER LEVELS IN CALIFORNIA HOUSE CATS:HOUSE DUST A PRIMARY SOURCE?

机译：加利福尼亚房屋用高溴化二苯醚的含量：房屋粉尘是主要来源？

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摘要

Abstract Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that act as endocrine disruptors, affecting thyroid hormone homeostasis. As a follow-up to a recent study showing high PBDE levels in household cats and linking PBDE levels with cat hyperthyroidism, we measured PBDEs, polychlorinated biphenyls (PCBs), and organochlorinated pesticides (OCPs> in serum samples from 26 California household cats (16 hyperthyroid, 10 controls) using liquid-liquid extraction and high-resolution gas chromatography/ high-resolution mass spectrometry. In the present pilot study, we found that PBDE levels in California house cats were extremely high (ΣPBDEs median = 2,904 ng/g lipid; range, 631-22,537 ng/g lipid). This is approximately 50 times higher than levels in California residents (ΣPBDEs geomcan = 62 ± 8.9 ng/g lipid, National Health and Nutrition Examination Survey), who have among the highest human levels in the world. Polybrominated diphenyl ethers congener patterns (BDE-99 major congener, BDE-209 significant) differed markedly from patterns found in California residents (BDE-47 major) or wildlife but resembled patterns found in house dust. Polychlorinated biphenyls and OCPs in cats were highly correlated, consistent with a shared dietary source or pathway of exposure, but did not correlate with PBDEs. This suggests a different source or pathway of exposure for PBDEs, which was most likely house dust. The authors found no evidence that linked levels of PBDEs, PCBs, or OCPs with hyperthyroidism. This may be because of the small sample size, competing or confounding risk factors, or complicated causal mechanisms.
机译：摘要多溴二苯醚（PBDEs）是溴化阻燃剂，可作为内分泌干扰物，影响甲状腺激素的体内稳态。作为最近一项研究的后续研究，该研究表明家猫的PBDE水平较高，并将PBDE水平与猫甲亢联系在一起，我们在26只加利福尼亚家猫的血清样本中测量了PBDEs，多氯联苯（PCB）和有机氯农药（OCPs）（16使用液-液萃取和高分辨率气相色谱/高分辨率质谱法检测甲状腺功能亢进症（10个对照）在当前的先期研究中，我们发现加利福尼亚家猫的PBDE水平非常高（ΣPBDEs中位数= 2,904 ng / g脂质；范围为631-22,537 ng / g脂质），这是人类水平最高的加利福尼亚州居民（ΣPBDEsgeomcan = 62±8.9 ng / g脂质，国家健康和营养调查）的水平大约高50倍。在世界范围内，多溴联苯醚同类物模式（BDE-99主要同类物，BDE-209重要）与在加利福尼亚居民（BDE-47主要同类物）或野生生物中发现的模式显着不同，但类似于d室内灰尘。猫中的多氯联苯和OCPs高度相关，与共享的饮食来源或接触途径一致，但与PBDEs无关。这表明多溴二苯醚的暴露源或暴露途径不同，这很可能是室内灰尘。作者没有发现将PBDEs，PCBs或OCP的水平与甲亢联系在一起的证据。这可能是由于样本量小，竞争因素或混杂风险因素或复杂的因果机制所致。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第2期|p.301-306|共6页
  • 作者

    WEIHONG GUO; JUNE-SOO PARK; YUNZHU WANG; STEVE GARDNER; CHRISTINA BAEK; MYRTO PETREAS; Kim HooPER;

  • 作者单位

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

    Albany Animal Hospital, Albany, California, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection Agency,Berkeley, California, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    house cat; hyperthyroidism; polybrominated diphenyl ethers; polychlorinated biphenyls; house dust;

    机译：家猫;甲状腺功能亢进;多溴二苯醚;多氯联苯;屋尘;

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