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首页> 外文期刊>Environmental toxicology and chemistry >RETENTION AND MATERNAL TRANSFER OF ENVIRONMENTALLY RELEVANT POLYBROMINATED DIBENZO-p-DIOXINS AND DIBENZOFURANS, POLYCHLORINATED DIBENZO-/?-DIOXINS AND DIBENZOFURANS, AND POLYCHLORINATED BIPHENYLS IN ZEBRAFISH (DANIO RERIO) AFTER DIETARY EXPOSURE
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RETENTION AND MATERNAL TRANSFER OF ENVIRONMENTALLY RELEVANT POLYBROMINATED DIBENZO-p-DIOXINS AND DIBENZOFURANS, POLYCHLORINATED DIBENZO-/?-DIOXINS AND DIBENZOFURANS, AND POLYCHLORINATED BIPHENYLS IN ZEBRAFISH (DANIO RERIO) AFTER DIETARY EXPOSURE

机译：斑马鱼（厌食症）中与环境有关的多溴联苯二恶英-对二恶英和二苯呋喃，多氯联苯二恶唑/？-二恶英和二苯呋喃以及多氯联苯的保留和物质转移

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摘要

High levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), mono- and non-ortho-polychlorinated biphenyls (PCBs), and polybrominated dibenzo-p-dioxins (PBDDs) are found in fish from coastal areas in the Baltic Sea, which may cause ecotoxicological effects. To increase our understanding of the persistency of the emerging pollutants polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), fish feed was spiked with 21 PBDD/Fs, 17 PCDD/Fs, and 30 PCBs and fed to zebrafish (Danio rerio). Concentrations in fish and eggs were examined during a 6- or 12-week uptake period, and a 6-week elimination period. Steady-state was reached for 2-, 3-, 7-, and/or 8-substituted tri- and tetra-BDD/Fs; 2,3,7,8-tetra-BDD (2,3,7,8-TeBDD) was the most strongly retained. Steady-state was not reached for tetra- to hexa-CDDs. Non-2,3,7,8 congeners showed little or no retention. Most PCBs had high retention and did not reach steady state. Half-lives decreased in the order PCBs > PCDD/Fs > PBDD/Fs. Concentrations of 2,3,7,8-substituted penta- to octa-CDD/Fs decreased with their degree of chlorination, suggesting that the rate-limiting factor for uptake is low bioavailability. Maternal transfer was observed for all retained compounds, with most transfer factors < 1, indicating that transfer rates are affected by the poor water solubility of the compounds. The limited retention of the major PBDD congeners found in Baltic Sea fish suggests that they are exposed to high or very high concentrations via either food or water.
机译：在波罗的海沿海地区的鱼类中发现了高含量的多氯二苯并对二恶英和二苯并呋喃（PCDD / Fs），单和非邻多氯联苯（PCB）以及多溴二苯对二恶英（PBDDs）海洋，可能引起生态毒理作用。为了加深对新兴污染物多溴二苯并对二恶英和二苯并呋喃（PBDD / Fs）的持久性的了解，鱼饲料中掺入了21种PBDD / F，17种PCDD / F和30种多氯联苯，并喂给斑马鱼（Danio rerio） ）。在6或12周的摄取期和6周的消除期中检查了鱼和蛋中的浓度。 2-，3-，7-和/或8-取代的三-和四-BDD / Fs达到稳态。 2,3,7,8-tetra-BDD（2,3,7,8-TeBDD）是保留最强的。四至六CDD达不到稳态。非2、3、7、8同系物几乎没有保留。大多数PCB具有很高的保留率，并且未达到稳态。半衰期按PCB> PCDD / Fs> PBDD / Fs的顺序减少。 2,3,7,8-取代的五-至八-CDD / Fs的浓度随其氯化程度而降低，这表明摄取的限速因素是低生物利用度。在所有保留的化合物中均观察到母体转移，大多数转移因子<1，表明转移速率受化合物不良的水溶性影响。在波罗的海鱼类中发现的主要PBDD同系物的保留量有限，这表明它们通过食物或水暴露于高浓度或极高浓度。

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