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首页> 外文期刊>Environmental toxicology and chemistry >METHODS FOR PREDICTING THE RATE CONSTANT FOR UPTAKE OF ORGANIC CHEMICALS FROM WATER BY FISH
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METHODS FOR PREDICTING THE RATE CONSTANT FOR UPTAKE OF ORGANIC CHEMICALS FROM WATER BY FISH

机译：用鱼预测从水中吸收有机化学物的速率常数的方法

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摘要

Bioaccumulation is an important information requirement for chemicals risk assessment. The most widely used test guideline for measuring bioaccumulation in fish is the OECD 305 test guideline and, in the future, it is likely to include a dietary exposure method for substances that are difficult to test by the more usual aqueous exposure route. This new method results in a biomagnification factor (BMF), whereas for regulatory purposes a bioconcentration factor (BCF) is often required. Therefore, being able to estimate a BCF quantitatively from the data generated in the dietary study would meet an accepted regulatory need. The information generated by the dietary study includes the depuration rate constant. To use these data to estimate a BCF, an estimate of the rate constant for uptake from water is needed, allowing a kinetic BCF to be calculated. The present study considers and tests methods that are currently available for predicting uptake rate constants from water using a database of bioconcentration data. A number of methods were found to perform similarly when tested with substances with a log K_(OW) range of approximately 3.5 to 8.2. The uncertainty in the estimated uptake rate constant was relatively large, however, even for the best performing methods.
机译：生物蓄积是化学品风险评估的重要信息要求。 OECD 305测试指南是用于测量鱼类中生物蓄积的最广泛使用的测试指南，在将来，它可能包括一种饮食暴露方法，用于难以通过更常见的水暴露途径进行测试的物质。这种新方法会产生生物放大因子（BMF），而出于监管目的，通常需要生物浓缩因子（BCF）。因此，能够从饮食研究中生成的数据定量估算BCF，将满足公认的监管需求。饮食研究产生的信息包括净化速率常数。为了使用这些数据估算BCF，需要估算从水中吸收的速率常数，从而可以计算出动态BCF。本研究考虑并测试了目前可用的利用生物浓度数据数据库从水中预测吸收速率常数的方法。当用log K_（OW）范围约为3.5到8.2的物质进行测试时，发现许多方法具有相似的性能。但是，即使对于性能最佳的方法，估计摄取速率常数的不确定性也相对较大。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第11期|2465-2471|共7页
  • 作者

    David N. Brooke; Michael J. Crookes; Daniel A.S. Merckel;

  • 作者单位

    Building Research Establishment, Watford, United Kingdom;

    Building Research Establishment, Watford, United Kingdom;

    Environment Agency, Red Kite House, Howbery Park, Wallingford, Oxfordshire, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    bioconcentration; bioaccumulation;

    机译：生物浓缩生物蓄积;

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