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首页> 外文期刊>Environmental toxicology and chemistry >EFFECTS OF GEMFIBROZIL ON LIPID METABOLISM, STEROIDOGENESIS, AND REPRODUCTION IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)
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EFFECTS OF GEMFIBROZIL ON LIPID METABOLISM, STEROIDOGENESIS, AND REPRODUCTION IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)

机译：吉非替尼对肥头子脂代谢，脂肪形成和生殖的影响

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摘要

Fibrates are a class of Pharmaceuticals that indirectly modulate cholesterol biosynthesis through effects on peroxisome proliferator-activated receptors. Gemfibrozil is a fibrate that has been detected in wastewater treatment plant influents, effluents, and drinking water. The objective of the present study was to assess the potential physiological and reproductive impacts of gemfibrozil on fathead minnows (Pimephales promelas). Fish were exposed to gemfibrozil in two different studies. The first was a short-term test with water concentrations of 0, 15, and 600 μg gemfibrozil/L, sampling after 2 or 8 d of exposure. Plasma cholesterol concentrations were significantly reduced in males exposed to 600 |xg gemfibrozil/L for 8 d. In addition, expression of several hepatic genes important to lipid metabolism was altered, suggesting that gemfibrozil does affect lipid metabolism in fish. A 21-d study was conducted to investigate further the effects on lipid metabolism and steroidogenesis as well as to assess potential impacts of gemfibrozil on reproduction. Fish were exposed to water concentrations of 0, 1.5, 15, 600, and 1,500 μg gemfibrozil/L. Exposure to 1,500 μg gemfibrozil/L caused a modest, but not significant, reduction in fecundity. However, gemfibrozil had no consistent effect on plasma cholesterol, triglycerides, or sex steroids after 21 d of exposure. The present study showed no evidence for significant physiological or reproductive impacts of gemfibrozil at an environmentally relevant concentration of 1.5 μg/L.
机译：贝特类药物是一类药物，可通过对过氧化物酶体增殖物激活受体的影响来间接调节胆固醇的生物合成。吉非贝齐是一种在废水处理厂的进水，污水和饮用水中检测到的贝特类药物。本研究的目的是评估吉非贝齐对黑头fat（Pimephales promelas）的潜在生理和生殖影响。在两项不同的研究中，将鱼暴露于吉非贝齐。第一个是短期测试，其中水浓度为0、15和600μg吉非贝齐/ L，在暴露2或8 d后取样。暴露于600μg吉非贝齐/ L 8天的男性血浆胆固醇浓度显着降低。此外，几个对脂质代谢重要的肝基因的表达也发生了改变，这表明吉非贝齐确实会影响鱼类的脂质代谢。进行了21天的研究，以进一步研究对脂质代谢和类固醇生成的影响，以及评估吉非贝齐对生殖的潜在影响。鱼暴露在浓度为0、1.5、15、600和1,500μg吉非贝齐/ L的水中。暴露于1,500μg吉非贝齐/ L会导致适度但不明显的生育力降低。然而，吉非贝齐暴露21 d后对血浆胆固醇，甘油三酸酯或性类固醇没有持续作用。本研究没有证据表明在与环境有关的浓度为1.5μg/ L的情况下，吉非贝齐具有显着的生理或生殖影响。

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  • 来源
    《Environmental toxicology and chemistry》 |2012年第11期|2615-2624|共10页
  • 作者

    Sarah Y. Skolness; Elizabeth J. Durhan; Kathleen M. Jensen; Michael D. Kahl; Elizabeth A. Makynen; Daniel L. Villeneuve; Gerald T. Ankley;

  • 作者单位

    Toxicology Graduate Program, University of Minnesota, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

    Office of Research and Development, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pharmaceutical; cholesterol; toxicity; fish; aromatase;

    机译：制药胆固醇;毒性;鱼;芳香化酶;

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