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首页> 外文期刊>Environmental toxicology and chemistry >TOXICITY EVALUATION OF SINGLE AND MIXED ANTIFOULING BIOCIDES USING THE STRONGYLOCENTROTUS INTERMEDIUS SEA URCHIN EMBRYO TEST
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TOXICITY EVALUATION OF SINGLE AND MIXED ANTIFOULING BIOCIDES USING THE STRONGYLOCENTROTUS INTERMEDIUS SEA URCHIN EMBRYO TEST

机译：中间型强心梭状藻海藻胚胎试验评估单种和混合抗微生物剂的毒性

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摘要

The present study evaluated the single and mixed toxicities of commonly used antifouling biocides (copper pyrithione, Sea nine 211, dichlofluanid, tolylfluanid, and Irgarol 1051) on the early embryogenesis of sea urchin Strongylocentrotus intermedius. Their toxicities were quantified in terms of the median effective concentration (EC50) reducing the embryogenesis success by 50%. For individual biocides to the embryos, the toxicity was in order of copper pyrithione > Sea nine 211 > tolylfluanid > dichlofluanid > Irgarol 1051. The toxicities of mixture (binary, ternary, quaternary, and quinary) of compounds, evaluated by toxic unit, additivity index, and mixture toxicity index, showed that the copper pyrithione-Sea nine 211 combination was the most toxic with the EC50 value of 7.87 nM in all mixtures. Synergistic enhancements of toxicity were observed for all mixtures except the combination of tolylfluanid-Sea nine 211, revealing antagonistic effect. Both the concentration addition and independent action concepts failed to accurately predict the mixture toxicities of the antifouling combinations; thus, a new log k_(OW)-based model was developed to predict the combined toxicities of these antifouling chemicals, which were capable of predicting the mixture toxicities of antifouling biocides (R~2 = 0.33).
机译：本研究评估了常用的防污杀虫剂（巯氧吡啶硫酮，海九211，双氯氟苯胺，甲苯基氟苯胺和Irgarol 1051）对海胆强壮梭菌的早期胚胎形成的毒性。根据中位数有效浓度（EC50）将其毒性降低50％，从而量化其毒性。对于单个杀生物剂而言，毒性依次为巯氧吡啶铜>海九211>甲苯氟苯胺>二氯氟苯胺> Irgarol1051。化合物的混合物（二元，三元，四元和五元）的毒性由毒性单位，加和性评估指数和混合物毒性指数表明，巯氧吡啶铜-海九211组合的毒性最高，在所有混合物中的EC50值为7.87 nM。除了甲苯基氟苯胺-海九211的组合以外，所有混合物均观察到协同增效的毒性，显示出拮抗作用。浓度增加和独立作用的概念均未能准确预测防污剂组合的混合物毒性。因此，建立了一个新的基于log k_（OW）的模型来预测这些防污化学品的组合毒性，该模型能够预测防污杀菌剂的混合物毒性（R〜2 = 0.33）。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第3期|p.692-703|共12页
  • 作者

    Heng Wang; Yan Li; Honghui Huang; Xue Xu; Yonghua Wang;

  • 作者单位

    College of Life Sciences, Northwest A and F University, Yangling, Shaanxi, China ,Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Guangzhou, China;

    School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning, China;

    Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Guangzhou, China;

    College of Life Sciences, Northwest A and F University, Yangling, Shaanxi, China;

    College of Life Sciences, Northwest A and F University, Yangling, Shaanxi, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    antifoulants; embryo; mixture toxicity; log kow; sea urchin;

    机译：防污剂胚胎混合物毒性;原木海胆;

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