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首页> 外文期刊>Environmental toxicology and chemistry >FATE OF THE ANTIFUNGAL DRUG CLOTRIMAZOLE IN AGRICULTURAL SOIL
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FATE OF THE ANTIFUNGAL DRUG CLOTRIMAZOLE IN AGRICULTURAL SOIL

机译：农业土壤中抗真菌药物克霉唑的去向

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Clotrimazole is a broad-spectrum antimycotic drug used for the treatment of dermatological and gynecological infections; it is incompletely broken down during sewage treatment and could potentially reach agricultural land through the application of municipal biosolids or wastewater. In the absence of any environmental fate data, we evaluated the persistence and dissipation pathways of ~3H-clotrimazole during laboratory incubations of agricultural soils. Clotrimazole was removed from a loam (time to dissipate 50% = 68 d), a sandy loam (time to dissipate 50% = 36 d), and a clay loam (time to dissipate 50% = 55 d), with formation of nonextractable residues being the major sink for 3H. Their parent compound had no significant mineralization, as evidenced by the lack of formation of ~3H_2O. Up to 15% of the applied radioactivity was recovered in the form of [3H]-(2-chlorophenyl)diphenyl methanol. The rate of clotrimazole dissipation in the loam soil did not vary with moisture content, but it was slower at a lower temperature (number of days to dissipate 50% = 275.6 d at 4℃). Addition of municipal biosolids to the loam soil did not vary the clotrimazole dissipation rate. In summary, the present study has established that clotrimazole is dissipated in soil, at rates that varied with soil texture and temperature. Clotrimazole dissipation was accompanied by the formation of nonextractable residues and detectable extractable residues of the transformation product (2-chlorophenyl)diphenyl methanol.
机译：克霉唑是一种广谱抗真菌药，用于治疗皮肤病和妇科感染。在污水处理过程中不完全分解，可能会通过应用市政生物固体或废水而到达农田。在没有任何环境命运数据的情况下，我们评估了在农业土壤的实验室培养过程中〜3H-克霉唑的持久性和耗散途径。将克霉唑从壤土（消散时间为50％= 68 d），沙质壤土（消散时间为50％= 36 d）和黏土壤土（消散时间为50％= 55 d）中移出，形成了不可提取的物质。残留物是3H的主要汇。他们的母体化合物没有明显的矿化作用，如〜3H_2O缺乏形成所证明。以[3 H]-（2-氯苯基）二苯基甲醇的形式回收了高达15％的所施加的放射性。克霉唑在壤土中的消散速度并没有随水分含量的变化而变化，但在较低的温度下（在4℃下消散50％的天数= 275.6 d）较慢。向壤土中添加市政生物固体不会改变克霉唑的消散率。总而言之，本研究已确定克霉唑在土壤中的耗散速率随土壤质地和温度的变化而变化。克霉唑消散伴随着转化产物（2-氯苯基）二苯甲醇的不可提取残基和可检测出的可提取残基的形成。

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