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首页> 外文期刊>Environmental toxicology and chemistry >WATERBORNE EXPOSURE TO CLODINAFOP-PROPARGYL DISRUPTS THE POSTERIOR AND VENTRAL DEVELOPMENT OF ZEBRAFISH EMBRYOS
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WATERBORNE EXPOSURE TO CLODINAFOP-PROPARGYL DISRUPTS THE POSTERIOR AND VENTRAL DEVELOPMENT OF ZEBRAFISH EMBRYOS

机译：斑马鱼胚胎的水分和腹侧发育对斑节菜纲的水生暴露有危害。

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摘要

Clodinafop-propargyl, an aryloxyphenoxypropionate herbicide, is widely used for the control of annual grasses. However, research focusing on the ecotoxicity of this herbicide is limited. The present study employed zebrafish (Danio rerio) as a model to investigate its developmental toxicity. Embryos were exposed to a range of concentrations from 0.2 μM to 5 μM starting at late cleavage stage (2h postfertilization, [hpf]) or late gastrulation stage (10 hpf). The results showed that the two exposure strategies had the same minimum teratogenic concentration of 0.6 μM but caused different groups of morphogenetic malformations. When exposure was initiated at 2 hpf, clodinafop-propargyl caused various embryonic phenotypes, including embryos with a fin gap in the ventral tail and embryos with coiled tail. When exposure was initiated at 10 hpf, clodinafop-propargyl resulted in failure of the tail to detach, in which the ventral tissues failed to grow out but instead adhered to the yolk extension, and the defect differed to various degrees among embryos. Similar effects were observed for embryos exposed to clodinafop, the metabolite of clodinafop-propargyl. Because these defects were mainly confined to the posterior and ventral region that derived from ventral blastoderm cells, we have evaluated the expression of the ventral mesoderm marker gene gata-1 and ventral ectoderm marker gene gata-3. No significant alteration was seen in gata-1 expression except for the expanded blood islands, whereas the expression of gata-3 was significantly reduced. Our findings showed that clodinafop-propargyl exposure disturbed embryonic patterning and fate specification of ventrally derived gastrula ectoderm cells.
机译：Clodinafop-炔丙基，一种芳氧基苯氧基丙酸酯除草剂，被广泛用于控制一年生草。但是，针对这种除草剂的生态毒性的研究是有限的。本研究采用斑马鱼（斑马鱼）作为模型来研究其发育毒性。从卵裂后期（受精后2小时，[hpf]）或胃化后期（10 hpf）开始，将胚胎暴露于0.2μM至5μM的浓度范围。结果表明，两种暴露策略的最小致畸浓度相同，为0.6μM，但会导致不同的形态发生畸形。当在2 hpf下开始暴露时，clodinafop-propargyl会导致各种胚胎表型，包括在腹侧尾巴中有鳍间隙的胚胎和具有盘绕尾巴的胚胎。当在10 hpf下开始暴露时，clodinafop-propargyl导致尾巴无法分离，在该尾巴中腹侧组织无法长出，而是附着在卵黄延伸上，并且缺陷在胚胎之间有不同程度的差异。对于暴露于clodinafop-炔丙基的代谢产物clodinafop的胚胎，观察到了类似的效果。由于这些缺陷主要局限于腹侧胚层细胞的后部和腹侧区域，因此我们评估了腹侧中胚层标记基因gata-1和腹侧外胚层标记基因gata-3的表达。除了扩张的血岛外，在gata-1表达中未见明显变化，而gata-3的表达则明显降低。我们的发现表明，氯丁那普-炔丙基暴露会扰乱腹侧衍生的胃胚外胚层细胞的胚胎形态和命运。

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  • 来源
    《Environmental toxicology and chemistry》 |2011年第7期|p.1576-1581|共6页
  • 作者

    Wenjun Gui; Qiaoxiang Dong; Shengli Zhou; Xingxing Wang; Shaoying Liu; Guonian Zhu;

  • 作者单位

    Zhejiang University, Hangzhou, Zhejiang, Peoples Republic of China;

    Wenzhou Medical College, Wenzhou, Zhejiang, Peoples Republic of China;

    Environmental Monitoring Center of Zhejiang Province, Hangzhou, Zhejiang, Peoples Republic of China;

    Zhejiang University, Hangzhou, Zhejiang, Peoples Republic of China;

    Zhejiang University, Hangzhou, Zhejiang, Peoples Republic of China;

    Zhejiang University, Hangzhou, Zhejiang, Peoples Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    clodinafop-propargyl; clodinafop acid; zebrafish; development; toxicity;

    机译：氯丁那普炔丙基;氯丁膦酸斑马鱼发展毒性;

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