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首页> 外文期刊>Environmental toxicology and chemistry >REVIEW OF THE REPRODUCTIVE BIOLOGY OF AMPHIPODS AND THEIR ENDOCRINE REGULATION: IDENTIFICATION OF MECHANISTIC PATHWAYS FOR REPRODUCTIVE TOXICANTS
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REVIEW OF THE REPRODUCTIVE BIOLOGY OF AMPHIPODS AND THEIR ENDOCRINE REGULATION: IDENTIFICATION OF MECHANISTIC PATHWAYS FOR REPRODUCTIVE TOXICANTS

机译：两栖动物的生殖生物学及其内分泌调节的综述：生殖毒素的机械途径的鉴定

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The reproductive biology of amphipods is reviewed to update the knowledge of the male and female reproductive processes of oogenesis and spermatogenesis as well as the endocrine systems of amphipods with the aim of advancing studies of reproductive toxicology. The ovarian and reproduction cycles of female gammaridean amphipods are closely correlated with the molt cycle, which is under direct control by the steroid hormone 20-hydroxyecdysone. The ability of males to copulate and subsequently for females to ovulate is restricted to the early postmolt period of the females. New developments in our understanding of the molt cycle and the endocrine regulatory pathways for reproduction using genomics techniques on other crustacean species are also discussed. The arthropod sterol ponasterone A or xenobiotics such as the fungicide fenarimol have been shown to elicit endocrine disruption in some crustaceans by acting as an agonist for 20-hydroxyecdysone at the ecdysone receptor or by inhibiting the synthesis of 20-hydroxyecdysone, respectively, resulting in disruption of molting and reproduction. Recent studies suggest that cadmium can inhibit secondary vitellogenesis in amphipods. Experimental approaches for examining the metabolic pathways associated with ecdysteroid hormonal signaling or metabolism, exoskeleton maintenance and molting, and the regulation of vitellogenin in amphipods are discussed. This information should aid in the identification of useful biomarkers for reproductive toxicity.
机译：对两栖类动物的生殖生物学进行了综述，以更新有关卵子发生的男性和女性生殖过程以及两栖类动物的内分泌系统的知识，以促进生殖毒理学的研究。雌性γ-马来类两栖动物的卵巢和生殖周期与蜕皮周期密切相关，蜕皮周期受类固醇激素20-羟基蜕皮激素的直接控制。雄性交配和随后雌性排卵的能力仅限于雌性的蜕皮后早期。还讨论了我们对使用其他甲壳类动物的基因组学技术对蜕皮周期和内分泌调节途径的理解的新进展。已显示节肢动物固醇ponasterone A或异生物素（如杀真菌剂芬那莫尔）可通过在蜕皮激素受体上充当20-羟基蜕皮激素的激动剂或分别抑制20-羟基蜕皮激素的合成而引起某些甲壳类动物的内分泌破坏。蜕皮和繁殖。最近的研究表明，镉可以抑制两栖动物的次级卵黄发生。讨论了与蜕皮甾体激素信号传导或代谢，外骨骼维持和蜕皮以及两栖动物中卵黄蛋白原的调节有关的代谢途径的实验方法。该信息应有助于鉴定有用的生殖毒性生物标志物。

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