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首页> 外文期刊>Environmental toxicology and chemistry >DATABASE OF PUBLISHED RETENTION FACTORS FOR IMMOBILIZED ARTIFICIAL MEMBRANE HPLC AND AN ASSESSMENT OF THE EFFECT OF EXPERIMENTAL VARIABILITY
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DATABASE OF PUBLISHED RETENTION FACTORS FOR IMMOBILIZED ARTIFICIAL MEMBRANE HPLC AND AN ASSESSMENT OF THE EFFECT OF EXPERIMENTAL VARIABILITY

机译：固定化人工膜HPLC公布的保留因子数据库和实验变异性评估

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摘要

A database was collated of published experimental logarithmic values for the relative retention factors (log k_(IAM)) measured using an immobilized artificial membrane column and high-performance liquid chromatography (IAM HPLC). Log k_(iam) is an alternative measure of hydrophobicity to the octanol/water partition coefficient (log k(ow))- While there are several accepted methods to measure log K_(ow), no standardized method exists to determine log k_(iam)- The database of collated log k_(IAM) values includes 13 key experimental parameters and contains 1,686 values for 555 compounds, which are predominantly polar organic compounds and include drug molecules and surfactants. These compounds are acidic, basic, and neutral and both ionized and un-ionized under the conditions of analysis. The data compiled demonstrated experimental variability for each experimental parameter considered, including column stationary phase, pH, temperature, and mobile phase. Reducing the experimental variability allowed for greater consistency in the datasets.
机译：使用固定化的人工膜色谱柱和高效液相色谱法（IAM HPLC），对已发布的相对保留因子的实验对数值（log k_（IAM））进行数据库整理。 Log k_（iam）是辛醇/水分配系数（log k（ow））的疏水性的另一种测量方法-虽然有几种公认的测量log K_（ow）的方法，但尚无用于确定log k_（iam的标准化方法） ）-整理后的log k_（IAM）值数据库包含13个关键实验参数，并包含555种化合物的1,686个值，这些化合物主要是极性有机化合物，包括药物分子和表面活性剂。这些化合物是酸性，碱性和中性的，在分析条件下既可离子化也可不离子化。汇总的数据表明，考虑到的每个实验参数（包括色谱柱固定相，pH，温度和流动相）的实验变异性。减少实验变异性可以使数据集具有更大的一致性。

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