...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental toxicology and chemistry >EVALUATING THE BIOTIC UGAND MODEL FOR TOXICITY AND THE ALLEVIATION OF TOXICITY IN TERMS OF CELL MEMBRANE SURFACE POTENTIAL
【24h】

EVALUATING THE BIOTIC UGAND MODEL FOR TOXICITY AND THE ALLEVIATION OF TOXICITY IN TERMS OF CELL MEMBRANE SURFACE POTENTIAL

机译：在细胞膜表面电位术语中评估生物乌金模型的毒性和消除毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The electrostatic nature of plant cell membrane (CM) plays significant roles in ionic interactions at the CM surface and hence in the biotic effects of metal ions. Increases in major cations (commonly Ca~(2+), Mg~(2+), H~+, Na~+, K~+, etc.) in bulk-phase medium reduce the negativity of CM surface electrical potential (ψ_0), but these slightly increase the driving force of a metal ion crossing CMs (surface-to-surface transmembrane potential difference, E_(m,surf)). Toxicologists commonly attributes the interactions between heavy metals and common cations (e.g., H~+, Ca~(2+), and Mg~(2+)) to competitions for binding sites at a hypothetical CM surface ligand. The ψ_0 effects are likely to be more important to metal toxicity and the alleviation of toxicity than site-specific competition. Models that do not consider ψ_0, such as the biotic ligand model (BLM) and the free ion activity model (FIAM), as usually employed are likely to lead to false conclusions about competition for binding at CM surface ligands. In the present study a model incorporating ψ_0 effects and site-specific competition effects was developed to evaluate metal (Cu~(2+), Co~(2+), and Ni~(2+)) toxicities threshold (EA50, causing 50% inhibition) for higher plants. In addition, the mechanisms for the effects of common cations on toxicity of metals were also explored in terms of CM surface electrical potential.
机译：植物细胞膜（CM）的静电性质在CM表面的离子相互作用中起着重要作用，因此在金属离子的生物作用中也起着重要作用。本体相介质中主要阳离子（通常为Ca〜（2 +），Mg〜（2 +），H〜+，Na〜+，K〜+等）的增加会降低CM表面电势的负电性（ψ_0 ），但是这些稍微增加了穿过CM的金属离子的驱动力（表面到表面跨膜电势差E_（m，surf））。毒理学家通常将重金属与常见阳离子（例如H〜+，Ca〜（2+）和Mg〜（2+））之间的相互作用归因于假设的CM表面配体争夺结合位点。 ψ_0效应对金属毒性和毒性缓解的影响可能比针对特定地点的竞争更为重要。通常不考虑ψ_0的模型，例如生物配体模型（BLM）和自由离子活性模型（FIAM），可能会导致关于在CM表面配体上竞争竞争的错误结论。在本研究中，开发了一个结合了ψ_0效应和特定场所竞争效应的模型来评估金属（Cu〜（2 +），Co〜（2+）和Ni〜（2+））毒性阈值（EA50，导致50抑制百分比）。此外，还从CM表面电势方面探讨了常见阳离子对金属毒性的影响机理。

著录项

  • 来源
    《Environmental toxicology and chemistry》 |2010年第7期|P.1503-1511|共9页
  • 作者

    Peng Wang; Dong-Mei Zhou; Lian-Zhen Li; Xiao-San Luo;

  • 作者单位

    State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, No. 71, East Beijing Road, Nanjing 210008, China Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

    rnState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, No. 71, East Beijing Road, Nanjing 210008, China;

    rnState Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, No. 71, East Beijing Road, Nanjing 210008, China Graduate School of Chinese Academy of Sciences, Beijing 100049, China;

    rnInstitute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    surface electrical potential; biotic ligand model; copper; cobalt; nickel;

    机译：表面电势生物配体模型铜;钴;镍;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号